Prescription medicine
Tradipitant Brand names: Nereus
Tradipitant (Nereus) is a prescription medicine with an FDA approval on record since 2025. No generic is listed in FDA's NDC Directory.
- No generic listed
Check it at the source: the tradipitant FDA label on DailyMed (effective July 16, 2026, Vanda Pharmaceuticals Inc.); the NDA 220152 record on Drugs@FDA; every tradipitant label on DailyMed.
Highlights of the record
FDA label of July 16, 2026; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026
Used for
From the label: indications and usageNEREUS is indicated for the prevention of vomiting induced by motion in adults.
Forms and strengths
- 85 mg
Capsule.
On the market
- Earliest approval on file
- December 30, 2025 Nereus, Vanda Pharms Inc; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- No generic approved
- Labelers listed (NDC)
- 1 of which 0 under generic applications, 1 under brand applications, repackagers included
- Last listed patent
- August 9, 2036 Nereus capsules; not a generic launch date
Supply and safety
- Pharmacy cost (NADAC)
- Not in the survey
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- No recall recorded
- FAERS reports
- 2 through July 30, 2026
What is tradipitant used for?
From the label: indications and usageNEREUS is indicated for the prevention of vomiting induced by motion in adults. NEREUS is a substance P/neurokinin 1 (NK1) receptor antagonist indicated for the prevention of vomiting induced by motion in adults.
Conditions named in the indications of tradipitant's FDA labels, with every medicine labeled for each:
Source: FDA drug label (NEREUS), Vanda Pharmaceuticals Inc., effective July 16, 2026 (SPL set 1a021ebd-16ac-4354-b4b2-1c3950c091e5), via openFDA; the full label on DailyMed
Is there a generic for tradipitant (Nereus)?
No generic tradipitant is approved (Drugs@FDA, October 8, 2026).
The Orange Book lists 4 patents for Nereus capsules, the last expiring on August 9, 2036. A patent or exclusivity date is not the date a generic goes on sale: court cases and settlements move it either way.
- 2025 earliest approval on file
- 2036 last listed patent
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do FAERS reports show for tradipitant?
The FDA Adverse Event Reporting System holds 2 reports that list tradipitant among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 0 are coded as a death and 0 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as tradipitant?
7 other medicines are given the same way (oral) and in the same FDA class as tradipitant or labeled mainly for the same use (nausea and vomiting), the same class first. Nausea and vomiting lists all 16 medicines labeled for it, by any route. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Ondansetron | Nausea and vomiting | 60 labelers | $0.0582 per tablet 4 mg tablet | No current entry |
| Meclizine | Nausea and vomiting | 24 labelers | $0.0442 per tablet 12.5 mg tablet | No current entry |
| Prochlorperazine | Nausea and vomiting | 29 labelers | $0.162 per tablet 10 mg tablet | No current entry |
| Dimenhydrinate | Nausea and vomiting | none listed | $0.0575 per tablet 50 mg tablet | No current entry |
| Aprepitant | Nausea and vomiting | 5 labelers | $46.42 per capsule 40 mg capsule | A presentation being discontinued |
| Doxylamine and pyridoxine | Nausea and vomiting | 4 labelers | $1.09 per unit 10-10 mg | No current entry |
| Trimethobenzamide | Nausea and vomiting | 4 labelers | n/a | No current entry |
Every medicine labeled for the same conditions as tradipitant
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to tradipitant
- 7 medicines for the same use
- Tradipitant side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other