Rifapentine Brand names: Priftin

What is rifapentine used for?

From the label: indications and usage

PRIFTIN is a rifamycin antimycobacterial drug indicated in patients 12 years of age and older for the treatment of active pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis in combination with one or more antituberculosis (anti-TB) drugs to which the isolate is susceptible. ( 1.1 ) PRIFTIN is indicated for the treatment of latent tuberculosis infection (LTBI) caused by M. tuberculosis in combination with isoniazid in patients 2 years of age and older at high risk of progression to TB disease. ( 1.2 ) See Full Prescribing Information for Limitations of Use. […]

FDA pharmacologic class: Rifamycin Antimycobacterial.

What does the patient leaflet for rifapentine say first?

The FDA-approved Medication Guide or Patient Information that comes with the medicine, in its own words.

From the patient leaflet: What is the most important information I should know about PRIFTIN?

PRIFTIN may cause serious side effects, including: Liver problems. PRIFTIN may cause serious liver problems. Your doctor may do a blood test to check your liver function before and while you take PRIFTIN. Stop taking PRIFTIN and call your doctor right away if you have any of the following signs and symptoms of liver problems: nausea stomach pain tiredness, yellowing skin or whites of your eyes vomiting loss of appetite dark urine Allergic reactions and flu-like symptoms. Allergic reactions and flu-like symptoms have happened in some people taking PRIFTIN. Signs and symptoms of an allergic reaction may include: low blood pressure (hypotension) hives cough with wheezing difficulty breathing red eyes (conjunctivitis) lower blood platelet levels Signs and symptoms of a flu-like reaction may include: weakness nausea and vomiting chills itching shortness of breath fainting tiredness headache aches sweats chest pain fast heartbeat muscle pain fever rash dizziness cough Severe skin reactions. Serious skin reactions such as Stevens-Johnson syndrome (SJS) and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome have happened in some people taking PRIFTIN. Stop taking PRIFTIN right away and call your doctor or get emergency help if you have any of the following symptoms: rash red and painful skin peeling or bleeding skin sores or blisters on the inside of your mouth or lips swollen face, lips, mouth tongue or throat flu-like symptoms

From the patient leaflet: How should I store PRIFTIN?

Store PRIFTIN at room temperature between 68°F to 77°F (20°C to 25°C). Keep PRIFTIN dry and away from heat. Keep PRIFTIN and all medicines out of reach of children.

Is there a generic for rifapentine (Priftin)?

The FDA approved the first generic rifapentine on June 23, 2026. 1 generic application is approved; 1 of it carries a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.

FDA's NDC Directory lists rifapentine from 1 labeler under a generic (ANDA) application and from 1 brand labeler. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it. In the latest NADAC survey pharmacies bought only the brand, so a generic may not be on sale yet.

What do pharmacies pay for rifapentine (Priftin)?

In CMS's NADAC survey of October 7, 2026, pharmacies paid $4.83 per Priftin 150 mg tablet, up 2% from $4.75 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.

Is rifapentine in shortage?

No rifapentine presentation is listed as in shortage in the FDA Drug Shortage Database (read October 8, 2026); its 1 record is all resolved, the latest updated August 6, 2026. ASHP keeps a separate shortage list, which can differ.

Every rifapentine presentation in the FDA shortage database

What does the rifapentine label say about other medicines?

The rifapentine label names 39 other medicines in its interaction, contraindication or warning sections. The labels of 34 other medicines name rifapentine. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.

Every other medicine the rifapentine label names

Other labels that name rifapentine

• Bedaquiline
• Cabotegravir
• Cabozantinib
• Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil
• Darunavir
• Doravirine
• Enzalutamide
• Erlotinib
• Etravirine
• Irinotecan
• Lenacapavir
• Nirmatrelvir and ritonavir
• Ranolazine
• Rilpivirine
• Sirolimus
• Sofosbuvir
• Tenofovir alafenamide

Check rifapentine against other medicines

What do FAERS reports show for rifapentine?

The FDA Adverse Event Reporting System holds 509 reports that list rifapentine among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 14 are coded as a death and 164 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.

Reports received each year

• 10
• 73
• 60
• 50
• 19
• 58
• 29
• 13
• 32
• 73
• 28

• 2016
• 2017
• 2018
• 2019
• 2020
• 2021
• 2022
• 2023
• 2024
• 2025
• 2026

The most reported reactions

• Drug Interaction (a use or a product term, not a reaction)67
• Pyrexia (named in the label)66
• Nausea (named in the label)52
• Fatigue (named in the label)42
• Hypertension40
• Vomiting (named in the label)40
• Off Label Use (a use or a product term, not a reaction)39
• Headache (named in the label)32

Side effects: the label's list and every FAERS reaction

What next?

Other rifamycin antimycobacterials

the pharmacologic class, with prices and generics

Rifapentine side effects

the label's list beside FAERS reports

Rifapentine shortage record

every presentation, company and date

Check an interaction

what two or more labels say about each other