What the FDA labels say about taking them together
Rifapentine and tenofovir alafenamide
Tenofovir alafenamide's FDA label of July 14, 2025 names rifapentine in its drug interactions section; the rifapentine label PlainMeds reads does not name tenofovir alafenamide. The tenofovir alafenamide label: “Coadministration of VEMLIDY with rifabutin, rifampin or rifapentine is not recommended.”
Check it at the source: the rifapentine FDA label on DailyMed (effective February 6, 2026, sanofi-aventis U.S. LLC); the tenofovir alafenamide FDA label on DailyMed (effective July 14, 2025, Gilead Sciences, Inc.).
What does the rifapentine label say about tenofovir alafenamide?
Rifapentine's label (effective February 6, 2026) does not name tenofovir alafenamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Priftin), sanofi-aventis U.S. LLC, effective February 6, 2026 (SPL set 3a64fb70-b85e-43d9-8bcd-7e893f568ae1), via openFDA; the full label on DailyMed
What does the tenofovir alafenamide label say about rifapentine?
Tenofovir alafenamide label, drug interactionsConcomitant Drug Class/Drug Name: Antimycobacterials:; Effect on Concentration ↓ = decrease.: ↓ tenofovir alafenamide; Clinical Comment: Coadministration of VEMLIDY with rifabutin, rifampin or rifapentine is not recommended.
Source: FDA drug label (VEMLIDY), Gilead Sciences, Inc., effective July 14, 2025 (SPL set 72e6b33c-0351-4070-9172-eeaa186c01d2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rifapentine | Tenofovir alafenamide | |
|---|---|---|
| Labeled for | n/a | Hepatitis B |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $4.83 per tablet 150 mg tablet | $51.98 per tablet 25 mg tablet |
| Shortage now | Resolved | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once