What the FDA labels say about taking them together
Darunavir and rifapentine
Darunavir's FDA label of August 29, 2025 names rifapentine in its drug interactions section; the rifapentine label PlainMeds reads does not name darunavir. The darunavir label: “Co-administration of PREZISTA/ritonavir with rifapentine is not recommended.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the rifapentine FDA label on DailyMed (effective February 6, 2026, sanofi-aventis U.S. LLC).
What does the darunavir label say about rifapentine?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: rifapentine; Effect on Concentration of Darunavir Or Concomitant Drug: ↓ darunavir; Clinical Comment: Co-administration of PREZISTA/ritonavir with rifapentine is not recommended.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the rifapentine label say about darunavir?
Rifapentine's label (effective February 6, 2026) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Priftin), sanofi-aventis U.S. LLC, effective February 6, 2026 (SPL set 3a64fb70-b85e-43d9-8bcd-7e893f568ae1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Rifapentine | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $4.83 per tablet 150 mg tablet |
| Shortage now | No current entry | Resolved |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once