What the FDA labels say about taking them together
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil and rifapentine
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil's FDA label of February 4, 2025 names rifapentine in its drug interactions section; the rifapentine label PlainMeds reads does not name cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil. The cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label: “Concomitant Drug Class/Drug Name: rifabutin rifapentine; Effect on Concentration ↑=Increase, ↓=Decrease: Coadministration of STRIBILD with rifabutin or rifapentine is not recommended.”
Check it at the source: the cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil FDA label on DailyMed (effective February 4, 2025, Gilead Sciences, Inc.); the rifapentine FDA label on DailyMed (effective February 6, 2026, sanofi-aventis U.S. LLC).
What does the cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label say about rifapentine?
Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil label, drug interactionsConcomitant Drug Class/Drug Name: rifabutin rifapentine; Effect on Concentration ↑=Increase, ↓=Decrease: Coadministration of STRIBILD with rifabutin or rifapentine is not recommended.
Source: FDA drug label (Stribild), Gilead Sciences, Inc., effective February 4, 2025 (SPL set 74ae2a93-b267-444c-8f0f-a2a6522260ee), via openFDA; the full label on DailyMed
What does the rifapentine label say about cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil?
Rifapentine's label (effective February 6, 2026) does not name cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Priftin), sanofi-aventis U.S. LLC, effective February 6, 2026 (SPL set 3a64fb70-b85e-43d9-8bcd-7e893f568ae1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat, elvitegravir, emtricitabine and tenofovir disoproxil | Rifapentine | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $150.14 per tablet Stribild tablet | $4.83 per tablet 150 mg tablet |
| Shortage now | No current entry | Resolved |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once