What the FDA labels say about taking them together
Acetaminophen/oxycodone and zidovudine
Acetaminophen/oxycodone's FDA label of December 23, 2025 names zidovudine in its drug interactions section; the zidovudine labels PlainMeds reads (3) do not name acetaminophen/oxycodone. The acetaminophen/oxycodone label: “Zidovudine The pharmacologic effects of zidovudine may be decreased because of enhanced non-hepatic or renal clearance of zidovudine.”
Check it at the source: the acetaminophen/oxycodone FDA label on DailyMed (effective December 23, 2025, Aurolife Pharma, LLC); the zidovudine FDA label on DailyMed (effective February 10, 2025, Aurobindo Pharma Limited).
What does the acetaminophen/oxycodone label say about zidovudine?
Acetaminophen/oxycodone label, drug interactionsZidovudine The pharmacologic effects of zidovudine may be decreased because of enhanced non-hepatic or renal clearance of zidovudine.
Source: FDA drug label (Oxycodone and Acetaminophen), Aurolife Pharma, LLC, effective December 23, 2025 (SPL set 69df20d9-b1d5-47dc-9ff0-29987284f8c7), via openFDA; the full label on DailyMed
What does the zidovudine label say about acetaminophen/oxycodone?
Zidovudine's label (effective February 10, 2025) and its 2 other brand-application labels do not name acetaminophen/oxycodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zidovudine), Aurobindo Pharma Limited, effective February 10, 2025 (SPL set 51abd2ce-6be1-412d-b806-5f24935ac5e3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen/oxycodone | Zidovudine | |
|---|---|---|
| Labeled for | Pain | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.183 per tablet 7.5-325 mg tablet | $0.464 per tablet 300 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once