What the FDA labels say about taking them together
Acetaminophen/oxycodone and propranolol
Acetaminophen/oxycodone's FDA label of December 23, 2025 names propranolol in its drug interactions section; the propranolol labels PlainMeds reads (4) do not name acetaminophen/oxycodone.
Check it at the source: the acetaminophen/oxycodone FDA label on DailyMed (effective December 23, 2025, Aurolife Pharma, LLC); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the acetaminophen/oxycodone label say about propranolol?
Acetaminophen/oxycodone label, drug interactionsBeta Blockers (Propranolol) Propranolol appears to inhibit the enzyme systems responsible for the glucuronidation and oxidation of acetaminophen.
Source: FDA drug label (Oxycodone and Acetaminophen), Aurolife Pharma, LLC, effective December 23, 2025 (SPL set 69df20d9-b1d5-47dc-9ff0-29987284f8c7), via openFDA; the full label on DailyMed
What does the propranolol label say about acetaminophen/oxycodone?
Propranolol's label (effective January 15, 2026) and its 3 other brand-application labels do not name acetaminophen/oxycodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen/oxycodone | Propranolol | |
|---|---|---|
| Labeled for | Pain | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.183 per tablet 7.5-325 mg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once