What the FDA labels say about taking them together
Acetaminophen/oxycodone and probenecid
Acetaminophen/oxycodone's FDA label of December 23, 2025 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name acetaminophen/oxycodone. The acetaminophen/oxycodone label: “Probenecid Probenecid may increase the therapeutic effectiveness of acetaminophen slightly.”
Check it at the source: the acetaminophen/oxycodone FDA label on DailyMed (effective December 23, 2025, Aurolife Pharma, LLC); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the acetaminophen/oxycodone label say about probenecid?
Acetaminophen/oxycodone label, drug interactionsProbenecid Probenecid may increase the therapeutic effectiveness of acetaminophen slightly.
Source: FDA drug label (Oxycodone and Acetaminophen), Aurolife Pharma, LLC, effective December 23, 2025 (SPL set 69df20d9-b1d5-47dc-9ff0-29987284f8c7), via openFDA; the full label on DailyMed
What does the probenecid label say about acetaminophen/oxycodone?
Probenecid's label (effective January 5, 2021) does not name acetaminophen/oxycodone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Acetaminophen/oxycodone | Probenecid | |
|---|---|---|
| Labeled for | Pain | Gout |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.183 per tablet 7.5-325 mg tablet | $0.636 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once