FDA pharmacologic class
Opioids (opioid agonists)
15 medicines are in FDA's class of opioid agonists (opioids): loperamide (Imodium), oxycodone (Oxycontin), morphine (Duramorph), tramadol (Conzip), hydromorphone (Dilaudid), fentanyl, methadone (Diskets), oxymorphone and 7 more; 15 combination products also contain one. 29 of the 30 are listed from generic labelers (FDA NDC Directory, October 8, 2026). The lowest pharmacy cost is tramadol hcl 50 mg tablet at $0.0248 per tablet (NADAC).
Which medicines are opioids?
| Medicine | Brand names | Generic labelers (all forms) | Pharmacy cost | Boxed warning | Shortage | Recalls since 2012 |
|---|---|---|---|---|---|---|
| Acetaminophen and hydrocodone | Norco | 36 labelers | $0.152 per tablet 10-325 mg tablet | Yes | No current entry | 14 |
| Loperamide | Anti-Diarrheal, Imodium | 95 labelers | $0.0549 per capsule 2 mg capsule | Yes | No current entry | 2 |
| Oxycodone | Oxycontin, Xtampza, Roxybond | 32 labelers | $0.0884 per tablet 5 mg tablet | Yes | No current entry | 11 |
| Morphine | Duramorph, Infumorph, Mitigo | 22 labelers | $0.226 per tablet 15 mg tablet | Yes | In shortage | 66 |
| Acetaminophen and oxycodone | Endocet, Prolate, Percocet | 29 labelers | $0.183 per tablet 7.5-325 mg tablet | Yes | A presentation being discontinued | 8 |
| Tramadol | Conzip | 39 labelers | $0.0248 per tablet 50 mg tablet | Yes | No current entry | 8 |
| Acetaminophen and codeine | none listed | 24 labelers | $0.256 per tablet 3 tablet | Yes | No current entry | 5 |
| Hydromorphone | Dilaudid | 13 labelers | $0.219 per tablet 4 mg tablet | Yes | In shortage | 30 |
| Fentanyl | none listed | 6 labelers | $1.79 per mL 100 mcg/2 mL vial | Yes | In shortage | 111 |
| Methadone | Diskets | 18 labelers | $0.177 per tablet 10 mg tablet | Yes | No current entry | 4 |
| Dimethicone and loperamide | Imodium | 33 labelers | $0.286 per unit Gs anti-diarrheal-antigas cplt | No | No current entry | 0 |
| Oxymorphone | none listed | 9 labelers | n/a | Yes | No current entry | 0 |
| Tapentadol | Nucynta | 4 labelers | $14.48 per tablet 100 mg tablet | Yes | No current entry | 0 |
| Hydrocodone | Hysingla | 1 labeler | $7.95 per capsule 15 mg capsule | Yes | No current entry | 0 |
| Acetaminophen and tramadol | none listed | 11 labelers | $0.116 per tablet 37.5-325 mg tablet | Yes | No current entry | 0 |
| Remifentanil | Ultiva | 2 labelers | n/a | Yes | In shortage | 0 |
| Levorphanol | none listed | 7 labelers | $10.65 per tablet 2 mg tablet | Yes | No current entry | 0 |
| Meperidine | Demerol | 3 labelers | $0.157 per mL 50 mg/5 mL solution | Yes | Listed; available | 0 |
| Acetaminophen, butalbital, caffeine and codeine | none listed | 5 labelers | $0.798 per capsule 50-325-40-30 mg capsule | Yes | No current entry | 0 |
| Homatropine methylbromide and hydrocodone | none listed | 3 labelers | $0.922 per tablet 5-1.5 mg tablet | Yes | No current entry | 5 |
| Codeine | none listed | 1 labeler | $0.726 per tablet 30 mg tablet | Yes | No current entry | 0 |
| Codeine and promethazine | none listed | 5 labelers | $0.0697 per mL Promethazine-codeine solution | Yes | No current entry | 0 |
| Hydrocodone and ibuprofen | none listed | 2 labelers | $0.487 per unit 7.5-200 | Yes | No current entry | 0 |
| Aspirin, butalbital, caffeine and codeine | none listed | 4 labelers | $1.00 per capsule Ascomp with codeine capsule | Yes | No current entry | 0 |
| Chlorpheniramine and hydrocodone | none listed | 2 labelers | $0.556 per mL Hydrocodone-chlorphen ER suspension | Yes | No current entry | 1 |
| Acetaminophen and caffeine and dihydrocodeine | Trezix | 1 labeler | n/a | Yes | No current entry | 0 |
| Aspirin and oxycodone | none listed | 1 labeler | n/a | Yes | No current entry | 0 |
| Chlorpheniramine and codeine | Tuxarin | none listed | n/a | Yes | No current entry | 0 |
| Codeine and phenylephrine and promethazine | none listed | 1 labeler | n/a | Yes | No current entry | 0 |
| Sufentanil | none listed | 1 labeler | n/a | Yes | In shortage | 1 |
Source: FDA Established Pharmacologic Class (NDC Directory, openFDA); CMS NADAC of October 7, 2026; FDA shortages and recalls (FDA files October 8, 2026)
What do pharmacies pay?
Each medicine's most widely listed form, per unit, in the NADAC survey: what pharmacies paid, not what a patient pays; strengths differ, so compare like with like.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price