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What the label lists and what reports show

Metyrapone side effects

Metyrapone's FDA label lists its adverse reactions in its own words. FAERS holds 977 reports naming it through July 30, 2026; the reaction reported most often, leaving out the conditions it is used for, product-use terms and outcomes, is nausea (80 reports).

  • No generic listed

Check it at the source: the metyrapone FDA label on DailyMed (effective May 19, 2026, ESTEVE PHARMACEUTICALS, S.A.); the FDA FAERS public dashboard.

What does the label list?

From the label: adverse reactions

The following adverse reactions associated with the use of Metopirone were identified in clinical trials or postmarketing reports. Because these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Cardiovascular System: Hypotension Gastrointestinal System: Nausea, vomiting, abdominal discomfort or pain Central Nervous System: Headache, dizziness, sedation Dermatologic System: Allergic rash Hematologic System: Leukopenia, anemia, and/or thrombocytopenia Adverse reactions include: hypotension, nausea, vomiting, abdominal discomfort or pain, headache, dizziness, sedation, allergic rash, leukopenia, anemia, and/or thrombocytopenia. ( 6 ) To report SUSPECTED ADVERSE REACTIONS, contact Esteve Pharmaceuticals, S.A. …

Source: FDA drug label, ESTEVE PHARMACEUTICALS, S.A., effective May 19, 2026 (SPL set 4046b167-7a46-8f4a-e063-6394a90a147f), via openFDA; the full label on DailyMed

What do FAERS reports show?

977 reports list metyrapone among the medicines taken, each a report of something that happened, not proof the medicine caused it; 120 are coded as a death and 314 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Of the 16 reactions below, 5 are named by the same term (in US spelling) in the label's adverse reactions, warnings or patient leaflet; a reaction the label does not name may still be there under another word, and a report does not show that the medicine caused it.

Reports received each year

The 25 most reported reactions

  • Off Label Use (a use or a product term, not a reaction)372
  • Nausea (named in the label)80
  • Drug Ineffective (a use or a product term, not a reaction)66
  • Vomiting (named in the label)52
  • Fatigue50
  • Adrenal Insufficiency (a use or a product term, not a reaction)43
  • Asthenia41
  • Dizziness (named in the label)40
  • Maternal Exposure During Pregnancy (a use or a product term, not a reaction)35
  • Pneumocystis Jirovecii Pneumonia35
  • Death (an outcome recorded in the report)34
  • Diarrhoea33
  • Anaemia (named in the label)27
  • Hypokalaemia27
  • Premature Baby27
  • Exposure During Pregnancy (a use or a product term, not a reaction)26
  • Hyperglycaemia26
  • Premature Delivery26
  • Cortisol Increased25
  • Product Dose Omission Issue (a use or a product term, not a reaction)25
  • Product Use In Unapproved Indication (a use or a product term, not a reaction)24
  • Foetal Exposure During Pregnancy (a use or a product term, not a reaction)22
  • Headache (named in the label)22
  • Malignant Neoplasm Progression22
  • Decreased Appetite20

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; reactions as MedDRA preferred terms

What next?

Metyrapone: the full record
label, generics, price, shortages, recalls
Side effects hub
the most reported medicines and reactions