LOW-VOLUME · SEX-BALANCED
codeine Side Effects
codeine (also sold as Codeine Sulfate) is a LOW-VOLUME FAERS extract #424 of 524 by FAERS report count. Still opens on SEX-BALANCED: 69% of sex-coded reports are female (1,826 F / 837 M).
Data updated 2026-05-15
- 3,245
- FAERS reports
Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.
codeine reporting skew - 69% of sex-coded reports are female (1,826 F / 837 M). Volume band LOW-VOLUME #424 of 524 by FAERS report count; caseload SIGNAL.
Thinner FAERS extract for codeine (Codeine Sulfate) (3,245 reports #424 of 524 by FAERS report count). 69% of sex-coded reports are female (1,826 F / 837 M). Sparse books still carry named reaction rows when present; not medical advice.
Counts from the openFDA FAERS extract (2004–2025). Stamps SIGNAL · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
DRUG HYPERSENSITIVITY leads 807 of 3,245 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (596 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (798 reports, 24.6%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| TOXICITY TO VARIOUS AGENTS | 224 |
| CARDIO-RESPIRATORY ARREST | 196 |
| DIARRHOEA | 191 |
| DYSPNOEA | 182 |
| ASTHENIA | 181 |
| DIZZINESS | 178 |
| HAEMORRHAGIC STROKE | 177 |
| ARTHRALGIA | 175 |
| TACHYCARDIA | 175 |
| HEADACHE | 174 |
| PRURITUS | 172 |
| FATIGUE | 171 |
| SEPSIS | 169 |
| DECREASED APPETITE | 168 |
| COUGH | 166 |
| MALAISE | 166 |
| FALL | 165 |
| INSOMNIA | 165 |
| VOMITING | 164 |
| ALTERED STATE OF CONSCIOUSNESS | 163 |
Reactions in Hospitalization Reports
Hospitalization mid-share (643, 19.8%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| NAUSEA | 106 |
| PAIN | 106 |
| DIARRHOEA | 102 |
| DYSPNOEA | 102 |
| ARTHRALGIA | 100 |
| HEADACHE | 94 |
| RASH | 88 |
| HYPERSENSITIVITY | 82 |
| MALAISE | 82 |
| FATIGUE | 78 |
| COUGH | 77 |
| DRUG HYPERSENSITIVITY | 77 |
| ABDOMINAL DISCOMFORT | 71 |
| ABDOMINAL PAIN UPPER | 70 |
| VOMITING | 70 |
| HYPERTENSION | 69 |
| ASTHENIA | 62 |
How to read codeine FAERS figures (SIGNAL · DEATH-HEAVY · HOSP-MID)
FAERS holds 3,245 voluntary reports linked to codeine (Codeine Sulfate), 2004-2025. Death is listed on 798 (24.6%). Hospitalization appears on 643 (19.8%). Top co-reported indication: Product Used For Unknown Indication.
Sparse extract - named reactions and SEX-BALANCED skew still differ by drug; not a complete safety profile.
Read with codeine
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-MID stamps.
ABS(total_reports) peer at 3,228 FAERS cases (Δ 17 lighter vs codeine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 3,267 FAERS cases (Δ 22 heavier vs codeine); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 3,268 FAERS cases (Δ 23 heavier vs codeine); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(total_reports) peer at 3,219 FAERS cases (Δ 26 lighter vs codeine); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 37.5 pp vs codeine's DEATH-HEAVY): CASELOAD · HOSP-MID.
codeine stamps DEATH-HEAVY · HOSP-MID; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload SIGNAL and the label guide.