LOW-VOLUME · HOSP-HEAVY
palonosetron Side Effects
palonosetron (also sold as Aloxi) is a LOW-VOLUME FAERS extract #421 of 524 by FAERS report count. Still opens on HOSP-HEAVY: 49.8% mention hospitalization (1,660 reports).
Data updated 2026-05-15
- 3,330
- FAERS reports
Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.
palonosetron: 49.8% mention hospitalization (1,660 reports). Death stamp DEATH-HEAVY; volume band LOW-VOLUME #421 of 524 by FAERS report count.
Thinner FAERS extract for palonosetron (Aloxi) (3,330 reports #421 of 524 by FAERS report count). 49.8% mention hospitalization (1,660 reports). Sparse books still carry named reaction rows when present; not medical advice.
Counts from the openFDA FAERS extract (2004–2025). Stamps SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
NAUSEA leads 399 of 3,330 reports
Who reports · age peak 45-64 (SEX-BALANCED)
Sex coding · SEX-BALANCED
Age peak 45-64 (1,245 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (519 reports, 15.6%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| DEATH | 174 |
| FATIGUE | 48 |
| NAUSEA | 43 |
| DIARRHOEA | 42 |
| DISEASE PROGRESSION | 40 |
| PNEUMONIA | 40 |
| FEBRILE NEUTROPENIA | 35 |
| ANAEMIA | 34 |
| ASTHENIA | 31 |
| SEPSIS | 30 |
| PYREXIA | 29 |
| VOMITING | 29 |
| DECREASED APPETITE | 28 |
| NEUTROPENIA | 27 |
| DYSPNOEA | 26 |
| MALIGNANT NEOPLASM PROGRESSION | 24 |
| RESPIRATORY FAILURE | 23 |
| THROMBOCYTOPENIA | 23 |
| CONSTIPATION | 22 |
Reactions in Hospitalization Reports
Hospitalization is HEAVY (1,660, 49.8% of the book). Top reactions in those rows:
| Reaction | Reports |
|---|---|
| FEBRILE NEUTROPENIA | 221 |
| NAUSEA | 173 |
| NEUTROPENIA | 155 |
| VOMITING | 134 |
| ANAEMIA | 122 |
| DIARRHOEA | 122 |
| PYREXIA | 115 |
| DYSPNOEA | 98 |
| DECREASED APPETITE | 91 |
| PNEUMONIA | 91 |
| ASTHENIA | 87 |
| THROMBOCYTOPENIA | 85 |
| FATIGUE | 77 |
| DEHYDRATION | 74 |
| ACUTE KIDNEY INJURY | 70 |
| CONSTIPATION | 70 |
| HYPOTENSION | 64 |
| ABDOMINAL PAIN | 62 |
| HYPOKALAEMIA | 55 |
How to read palonosetron FAERS figures (SIGNAL · DEATH-HEAVY · HOSP-HEAVY)
FAERS holds 3,330 voluntary reports linked to palonosetron (Aloxi), 2004-2025. Death is listed on 519 (15.6%). Hospitalization appears on 1,660 (49.8%). Top co-reported indication: Product Used For Unknown Indication.
Sparse extract - named reactions and SEX-BALANCED skew still differ by drug; not a complete safety profile.
Read with palonosetron
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-HEAVY stamps.
ABS(total_reports) peer at 3,344 FAERS cases (Δ 14 heavier vs palonosetron); DEATH-MARKED · HOSP-MID · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 3,350 FAERS cases (Δ 20 heavier vs palonosetron); DEATH-MARKED · HOSP-MID · MALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 3,268 FAERS cases (Δ 62 lighter vs palonosetron); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(total_reports) peer at 3,267 FAERS cases (Δ 63 lighter vs palonosetron); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 46.5 pp vs palonosetron's DEATH-HEAVY): CASELOAD · HOSP-MID.
palonosetron stamps DEATH-HEAVY · HOSP-HEAVY; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload SIGNAL and the label guide.