LOW-VOLUME · FEMALE-LED
metaxalone Side Effects
metaxalone (also sold as Skelaxin) is a LOW-VOLUME FAERS extract #422 of 524 by FAERS report count. Still opens on FEMALE-LED: 73% of sex-coded reports are female (2,234 F / 812 M).
Data updated 2026-05-15
- 3,268
- FAERS reports
Thinner FAERS book - still a temporal association ledger, not proof of cause. Methodology.
metaxalone reporting skew - 73% of sex-coded reports are female (2,234 F / 812 M). Volume band LOW-VOLUME #422 of 524 by FAERS report count; caseload SIGNAL.
Thinner FAERS extract for metaxalone (Skelaxin) (3,268 reports #422 of 524 by FAERS report count). 73% of sex-coded reports are female (2,234 F / 812 M). Sparse books still carry named reaction rows when present; not medical advice.
Counts from the openFDA FAERS extract (2004–2025). Stamps SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
COMPLETED SUICIDE leads 261 of 3,268 reports
FEMALE-LED reporters · age peak 45-64
Female-led reporters (73% of sex-coded rows)
Age peak 45-64 (1,002 reports)
FAERS filings rising toward 2025
Reactions in Death Reports
Death-mentioned subset is HEAVY here (599 reports, 18.3%). Top co-reported reactions in that subset - voluntary, not causal.
| Reaction | Reports |
|---|---|
| COMPLETED SUICIDE | 261 |
| TOXICITY TO VARIOUS AGENTS | 155 |
| DEATH | 113 |
| DRUG ABUSE | 54 |
| CARDIO-RESPIRATORY ARREST | 45 |
| CARDIAC ARREST | 37 |
| OVERDOSE | 34 |
| RESPIRATORY ARREST | 34 |
| ACCIDENTAL DEATH | 26 |
| RENAL FAILURE | 24 |
| POISONING | 23 |
| COMA | 21 |
| DRUG TOXICITY | 15 |
| ACUTE KIDNEY INJURY | 14 |
| CARDIAC FAILURE CONGESTIVE | 13 |
| HYPOTENSION | 13 |
| HYPERTENSION | 12 |
| INTENTIONAL DRUG MISUSE | 12 |
| RESPIRATORY FAILURE | 12 |
| BRAIN OEDEMA | 11 |
Reactions in Hospitalization Reports
Hospitalization mid-share (771, 23.6%). Co-reported reactions:
| Reaction | Reports |
|---|---|
| FALL | 60 |
| PNEUMONIA | 59 |
| NAUSEA | 54 |
| RENAL FAILURE | 52 |
| SEROTONIN SYNDROME | 50 |
| PAIN | 48 |
| FATIGUE | 47 |
| DIARRHOEA | 45 |
| DYSPNOEA | 45 |
| DIZZINESS | 43 |
| VOMITING | 42 |
| HEADACHE | 39 |
| WEIGHT DECREASED | 37 |
| HYPERTENSION | 36 |
| TOXICITY TO VARIOUS AGENTS | 36 |
| DRUG INTERACTION | 35 |
| ACUTE KIDNEY INJURY | 32 |
| OVERDOSE | 30 |
| CONSTIPATION | 28 |
| MALAISE | 27 |
How to read metaxalone FAERS figures (SIGNAL · DEATH-HEAVY · HOSP-MID)
FAERS holds 3,268 voluntary reports linked to metaxalone (Skelaxin), 2004-2025. Death is listed on 599 (18.3%). Hospitalization appears on 771 (23.6%). Top co-reported indication: Product Used For Unknown Indication.
Sparse extract - named reactions and FEMALE-LED skew still differ by drug; not a complete safety profile.
Read with metaxalone
Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-HEAVY · HOSP-MID stamps.
ABS(total_reports) peer at 3,267 FAERS cases (Δ 1 lighter vs metaxalone); DEATH-HEAVY · HOSP-MID · FEMALE-LED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 3,245 FAERS cases (Δ 23 lighter vs metaxalone); DEATH-HEAVY · HOSP-MID · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 3,228 FAERS cases (Δ 40 lighter vs metaxalone); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(total_reports) peer at 3,219 FAERS cases (Δ 49 lighter vs metaxalone); DEATH-HEAVY · HOSP-HEAVY · SEX-BALANCED vs this page's SIGNAL · DEATH-HEAVY · HOSP-MID · FEMALE-LED.
ABS(death_share) pole at 62.1% death-mentioned reports (Δ 43.8 pp vs metaxalone's DEATH-HEAVY): CASELOAD · HOSP-MID.
metaxalone stamps DEATH-HEAVY · HOSP-MID; FAERS outcome shares are signal-detection rates, not incidence. Read them next to caseload SIGNAL and the label guide.