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PlainMeds

Medicines labeled for the same conditions

Alternatives to sacubitril and valsartan

17 other medicines are given the same way (oral) and in the same FDA class as sacubitril and valsartan or labeled mainly for the same use (heart failure); 1 is in its class, neprilysin inhibitors: candesartan; the others include 3 aldosterone antagonists, 2 thiazide diuretics and 2 loop diuretics (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.478 per candesartan cilexetil 16 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).

Which medicines are labeled for the same conditions as sacubitril and valsartan?

Heart failure lists all 37 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.

Medicine and FDA classShared indicationGeneric labelers (oral)Pharmacy costBoxed warningShortage
Sacubitril and valsartanneprilysin inhibitorthis medicine27 labelers$0.533 per unit 49-51 mgYesNo current entry
Candesartanangiotensin 2 receptor blocker · same classHeart failure8 labelers$0.478 per tablet 16 mg tabletYesNo current entry
Carvedilolalpha-adrenergic blockerHeart failure41 labelers$0.0179 per tablet 6.25 mg tabletNoNo current entry
Spironolactonealdosterone antagonistHeart failure38 labelers$0.0426 per tablet 25 mg tabletNoA presentation being discontinued
Hydrochlorothiazidethiazide diureticHeart failure44 labelers$0.0115 per tablet 25 mg tabletNoA presentation being discontinued
Furosemideloop diureticHeart failure33 labelers$0.026 per tablet 20 mg tabletNoIn shortage
Bumetanideloop diureticHeart failure24 labelers$0.108 per tablet 1 mg tabletYesResolved
Digoxincardiac glycosideHeart failure21 labelers$0.133 per tablet 125 mcg tabletNoNo current entry
Ivabradinehyperpolarization-activated cyclic nucleotide-gated channel blockerHeart failure11 labelers$0.761 per tablet 5 mg tabletNoA presentation being discontinued
Eplerenonealdosterone antagonistHeart failure9 labelers$0.308 per tablet 25 mg tabletNoNo current entry
Hydrochlorothiazide and spironolactonealdosterone antagonistHeart failure6 labelers$0.483 per tablet 25-25 tabletNoNo current entry
Empagliflozinsodium-glucose cotransporter 2 inhibitorHeart failurenone listed$11.19 per tablet 10 mg tabletNoNo current entry
Triamterenepotassium-sparing diureticHeart failure3 labelers$5.98 per capsule 50 mg capsuleYesNo current entry
Hydralazine and isosorbide dinitratearteriolar vasodilatorHeart failure3 labelers$0.714 per tablet 20-37.5 mg tabletNoNo current entry
Vericiguatsoluble guanylate cyclase stimulatorHeart failurenone listed$22.72 per tablet 10 mg tabletYesNo current entry
Sotagliflozinsodium-glucose cotransporter 2 inhibitorHeart failurenone listed$20.37 per tablet 200 mg tabletNoNo current entry
Amiloride and hydrochlorothiazidepotassium-sparing diureticHeart failure1 labeler$0.450 per tablet 5-50 mg tabletYesNo current entry
Chlorothiazidethiazide diureticHeart failurenone listedn/aNoA presentation being discontinued

Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)

What do pharmacies pay for each?

The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What next?

Sacubitril and valsartan: the full record
label, generics, price, shortages, recalls