Prescription medicine
Desflurane Brand names: Suprane
Desflurane (Suprane) is a prescription medicine with an FDA approval on record since 1992. FDA's NDC Directory lists it from 1 generic labeler.
- Generic listed
- A presentation discontinued
Check it at the source: the desflurane FDA label on DailyMed (effective October 14, 2025, Baxter Healthcare Corporation); the NDA 20118 record on Drugs@FDA; every desflurane label on DailyMed.
Highlights of the record
FDA label of October 14, 2025; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026
Used for
From the label: indications and usageSUPRANE, a general anesthetic, is an inhalation agent indicated:
for induction and/or maintenance of anesthesia in adults ( 1.1 )
for maintenance of anesthesia in pediatric patients following induction with agents other than SUPRANE and intubation.
Forms and strengths
- 240 ml/240ml
Liquid.
On the market
- Earliest approval on file
- September 18, 1992 Suprane, Baxter Hlthcare; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 1 first February 26, 2018; 0 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 3 of which 1 under generic applications, 2 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- Not in the survey
- Shortage (FDA)
- None current 1 past records
- Recalls by its makers (FDA)
- 1 since 2020 0 Class I among all firms' recalls; latest October 6, 2020
- FAERS reports
- 1,699 through July 30, 2026
What is desflurane used for?
From the label: indications and usageSUPRANE, a general anesthetic, is an inhalation agent indicated:
for induction and/or maintenance of anesthesia in adults ( 1.1 )
for maintenance of anesthesia in pediatric patients following induction with agents other than SUPRANE and intubation. 1.1 Induction of Anesthesia SUPRANE is indicated as an inhalation agent for induction of anesthesia for inpatient and outpatient surgery in adults. […]
FDA pharmacologic class: General Anesthetic.
Source: FDA drug label (SUPRANE), Baxter Healthcare Corporation, effective October 14, 2025 (SPL set 3fe3d468-d283-4dd0-a1a7-29291a9b2d0b), via openFDA; the full label on DailyMed
Is there a generic for desflurane (Suprane)?
The FDA approved the first generic desflurane on February 26, 2018. 1 generic application is approved; 0 of it carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists desflurane from 1 labeler under a generic (ANDA) application and from 2 brand labelers. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1992 earliest approval on file
- 2018 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
Is desflurane in shortage?
No desflurane presentation is listed as in shortage in the FDA Drug Shortage Database (read October 8, 2026); its 1 record is all marked to be discontinued, the latest updated July 2, 2026. ASHP keeps a separate shortage list, which can differ.
| Presentation | Company | Status | Updated |
|---|---|---|---|
| Desflurane, Liquid for Inhalation, 240 mL/240 mL (NDC 0781-6172-86) | Jiangsu Hengrui Pharmaceuticals Co. (US Agent eVenus Pharmaceutical Laboratories, Inc.) | To Be Discontinued | July 2, 2026 |
Source: FDA Drug Shortage Database via openFDA, updated October 8, 2026
Has desflurane been recalled?
The FDA's Enforcement Report lists 1 recall naming desflurane since 2020: 0 Class I (the most serious), 0 Class II, 1 Class III; 0 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| October 6, 2020 | Class III | eVenus Pharmaceutical Laboratories | DEFECTIVE CONTAINER: Desflurane Liquid for Inhalation 240 mL may be leaking. |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the desflurane label say about other medicines?
The desflurane label names 8 other medicines in its interaction, contraindication or warning sections. The labels of 4 other medicines name desflurane. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Atracurium | drug interactions | Desflurane Concentration; Pancuronium; Atracurium; Succinylcholine; Vecuronium |
| Dantrolene | warnings and precautions | Malignant Hyperthermia: Malignant hyperthermia may occur, especially in individuals with known or suspected susceptibility based on genetic factors or family history. Discontinue triggering agents, administer intravenous dantrolene sodium, and apply supportive therapies. |
| Epinephrine | drug interactions | Similar to isoflurane, SUPRANE does not predispose to premature ventricular arrhythmias in the presence of exogenously infused epinephrine in swine. |
| Fentanyl | drug interactions | This effect is shown in Table 3 for intravenous midazolam (25-50 µg/kg) and intravenous fentanyl (3-6 µg/kg) in patients of two different age groups. |
| Isoflurane | drug interactions | Similar to isoflurane, SUPRANE does not predispose to premature ventricular arrhythmias in the presence of exogenously infused epinephrine in swine. |
| Midazolam | drug interactions | This effect is shown in Table 3 for intravenous midazolam (25-50 µg/kg) and intravenous fentanyl (3-6 µg/kg) in patients of two different age groups. |
| Succinylcholine | drug interactions | Desflurane Concentration; Pancuronium; Atracurium; Succinylcholine; Vecuronium |
| Vecuronium | drug interactions | Desflurane Concentration; Pancuronium; Atracurium; Succinylcholine; Vecuronium |
Other labels that name desflurane
Source: FDA drug label (SUPRANE), Baxter Healthcare Corporation, effective October 14, 2025 (SPL set 3fe3d468-d283-4dd0-a1a7-29291a9b2d0b), via openFDA; the full label on DailyMed
What do FAERS reports show for desflurane?
The FDA Adverse Event Reporting System holds 1,699 reports that list desflurane among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 112 are coded as a death and 654 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
Reports received each year
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What next?
- Other general anesthetics
- the pharmacologic class, with prices and generics
- Desflurane side effects
- the label's list beside FAERS reports
- Desflurane shortage record
- every presentation, company and date
- Check an interaction
- what two or more labels say about each other