What the FDA labels say about taking them together
Desflurane and succinylcholine
Desflurane's FDA label of October 14, 2025 names succinylcholine in its drug interactions section, and succinylcholine's label names desflurane too. The desflurane label: “Desflurane Concentration; Pancuronium; Atracurium; Succinylcholine; Vecuronium”
Check it at the source: the desflurane FDA label on DailyMed (effective October 14, 2025, Baxter Healthcare Corporation); the succinylcholine FDA label on DailyMed (effective August 18, 2026, Hospira, Inc.).
What does the desflurane label say about succinylcholine?
Desflurane label, drug interactionsDesflurane Concentration; Pancuronium; Atracurium; Succinylcholine; Vecuronium
Desflurane label, warnings and precautionsThe risk of developing malignant hyperthermia increases with the concomitant administration of succinylcholine and volatile anesthetic agents.
Source: FDA drug label (SUPRANE), Baxter Healthcare Corporation, effective October 14, 2025 (SPL set 3fe3d468-d283-4dd0-a1a7-29291a9b2d0b), via openFDA; the full label on DailyMed
What does the succinylcholine label say about desflurane?
Succinylcholine label, drug interactionsDRUG INTERACTIONS Drugs that May Enhance the Neuromuscular Blocking Action of Succinylcholine: promazine, oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, β-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, isoflurane, desflurane, metoclopramide, terbutaline, and drugs that reduce plasma cholinesterase activity.
Source: FDA drug label (QUELICIN), Hospira, Inc., effective August 18, 2026 (SPL set fb08161e-7711-406d-e7b3-ea4515c07983), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Desflurane | Succinylcholine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once