Trimethoprim and Glipizide Interaction
Drug interaction information between Trimethoprim and Glipizide.
Trimethoprim and Glipizide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Trimethoprim and Glipizide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Trimethoprim slows down how your body breaks down glipizide, which can make your blood sugar drop too low.
FDA Label Information
Sulfamethoxazole and trimethoprim potentiates the effect of oral hypoglycemics that are metabolized by CYP2C8 (e.g., pioglitazone, repaglinide, and rosiglitazone) or CYP2C9 (e.g., glipizide and glyburide) or eliminated renally via OCT2 (e.g., metformin).
Trimethoprim Also Interacts With
- Theophylline major
- Prenatal Multivitamin moderate
- Spironolactone moderate
- Spironolactone (Acne) moderate
- Metformin minor
Glipizide Also Interacts With
- Fluconazole minor
- Colesevelam minor
- Probenecid minor
- Phenytoin minor
- Lovastatin minor
Frequently Asked Questions
What SPL severity band is on file for Trimethoprim + Glipizide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trimethoprim has 22 labeled pairs on file vs Glipizide's 8. In the minor band specifically: Trimethoprim has 18 (also Metformin, Warfarin, Methotrexate, Pioglitazone); Glipizide has 8 (also Fluconazole, Colesevelam, Probenecid, Phenytoin).
What mechanism field is on file for Trimethoprim and Glipizide?
Trimethoprim slows down how your body breaks down glipizide, which can make your blood sugar drop too low.
Trimethoprim carries more major-labeled pairs than Glipizide
SPL source-record counts only. This page's band is minor · classes on file: Trimethoprim (Dihydrofolate Reductase Inhibitor); Glipizide (Sulfonylurea).
Trimethoprim has 1 major-labeled pair vs Glipizide's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 18 minor · 22 total
- Other minor peers for Trimethoprim
- Metformin
- Warfarin
- Methotrexate
- Pioglitazone
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Glipizide
- Fluconazole
- Colesevelam
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.