Trimethoprim and Theophylline Interaction
Drug interaction information between Trimethoprim and Theophylline.
Trimethoprim and Theophylline have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Trimethoprim and Theophylline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication has been shown to have no important effect on how quickly theophylline is cleared from your body.
FDA Label Information
albuterol, systemic and inhaled mebendazole amoxicillin medroxyprogesterone ampicillin, with or without sulbactam methylprednisolone atenolol metronidazole azithromycin metoprolol caffeine, dietary ingestion nadolol cefaclor nifedipine co-trimoxazole (trimethoprim and sulfamethoxazole) nizatidine diltiazem norfloxacin dirithromycin ofloxacin enflurane omeprazole famotidine prednisone, prednisolone felodipine ranitidine finasteride rifabutin hydrocortisone roxithromycin isoflurane Sorbitol (purgative doses do not inhibit theophylline absorption) isoniazid sucralfate isradipine terbutaline,...
Trimethoprim Also Interacts With
- Prenatal Multivitamin moderate
- Spironolactone moderate
- Spironolactone (Acne) moderate
- Metformin minor
- Glipizide minor
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Frequently Asked Questions
What SPL severity band is on file for Trimethoprim + Theophylline?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Trimethoprim's 22. In the major band specifically: Trimethoprim has 1; Theophylline has 27 (also Metoprolol, Albuterol, Omeprazole, Amoxicillin).
What mechanism field is on file for Trimethoprim and Theophylline?
This medication has been shown to have no important effect on how quickly theophylline is cleared from your body.
Theophylline carries more major-labeled pairs than Trimethoprim
SPL source-record counts only. This page's band is major · classes on file: Trimethoprim (Dihydrofolate Reductase Inhibitor); Theophylline (Methylxanthine Bronchodilator).
Theophylline has 27 major-labeled pairs vs Trimethoprim's 1.
1 major · 3 moderate · 18 minor · 22 total
Trimethoprim has no other major-band peer in this dataset besides Theophylline.
27 major · 5 moderate · 54 minor · 86 total
- Other major peers for Theophylline
- Metoprolol
- Albuterol
- Omeprazole
- Amoxicillin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.