glipizide vs trimethoprim
Side-by-side comparison of glipizide and trimethoprim. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Sulfamethoxazole and trimethoprim potentiates the effect of oral hypoglycemics that are metabolized by CYP2C8 (e.g., pioglitazone, repaglinide, and rosiglitazone) or CYP2C9 (e.g., glipizide and glyburide) or eliminated renally via OCT2 (e.g., metformin).
Recommendation: You should monitor your blood sugar closely and watch for signs of it being too low, like feeling shaky or dizzy.
Glucotrol
Primsol
Glipizide is a medicine that helps lower blood sugar in adults with type 2 diabetes. It works along with diet and exercise.
This medicine contains sulfamethoxazole and trimethoprim. It is an antibiotic that fights bacteria in your body.
Glipizide is used to improve blood sugar control in adults who have type 2 diabetes. It is meant to be used in addition to diet and exercise. This medicine helps your body use insulin better and lowers blood sugar levels.
This medicine can treat urinary tract infections, ear infections in children, and bronchitis in adults. It also treats shigellosis, a type of diarrhea. It can also treat or prevent Pneumocystis jiroveci pneumonia, and treat traveler's diarrhea.
Glipizide belongs to a class of drugs called sulfonylureas. It works by helping your pancreas release more insulin. Insulin then helps your body use sugar from the food you eat.
This medicine works by stopping bacteria from making folic acid. Bacteria need folic acid to grow and multiply. By blocking folic acid production, the medicine kills the bacteria.
- • Nausea
- • Diarrhea
- • Skin rash
- • Dizziness
- • Drowsiness
- • Nausea
- • Vomiting
- • Loss of appetite
- • Skin rash
- • Hives
- High blood sugar 6,673
- Feeling sick to your stomach 4,442
- Loose, watery stools 3,266
- Feeling tired 2,999
- Weight loss 2,811
- Nausea 945
- Diarrhoea 848
- Headache 835
- Malaise 815
- Pyrexia 721
Glipizide can cause low blood sugar (hypoglycemia). Watch for symptoms like shakiness, sweating, confusion, and rapid heartbeat. If you have very low blood sugar, get medical help right away. Certain drugs can increase the risk of low blood sugar. Tell your doctor about all the medicines you take.
Rarely, sulfonamide drugs like this one have caused severe reactions. These include Stevens-Johnson syndrome, toxic epidermal necrolysis, liver damage, and blood problems. Tell your doctor right away if you have a fever, rash, blisters, mouth sores, or signs of infection.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if glipizide will harm your unborn baby. Talk to your doctor about the best way to control your blood sugar during pregnancy. It is not recommended to breastfeed while taking this medication.
Tell your doctor if you are pregnant or plan to become pregnant. This medicine may not be safe for your baby. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
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How to Read This glipizide vs trimethoprim Comparison
glipizide is classified in the Sulfonylurea drug class, while trimethoprim sits within the Dihydrofolate Reductase Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, glipizide has 20,191 submissions while trimethoprim has 4,164. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to trimethoprim slows down how your body breaks down glipizide, which can make your blood sugar drop too low.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between glipizide and trimethoprim - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.