Tretinoin and Voriconazole Interaction
Drug interaction information between Tretinoin and Voriconazole.
Tretinoin and Voriconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tretinoin and Voriconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Voriconazole stops the body from breaking down tretinoin, which can lead to high levels of the drug in your blood.
What To Do
Your doctor should check you often for high calcium levels or signs of increased pressure in the brain.
FDA Label Information
Tretinoin (CYP3A4 Inhibition) Although Not Studied, Voriconazole may Increase Tretinoin Concentrations and Increase the Risk of Adverse Reactions Frequent monitoring for signs and symptoms of pseudotumor cerebri or hypercalcemia.
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Frequently Asked Questions
Can I take Tretinoin and Voriconazole together?
This is a moderate interaction. Your doctor should check you often for high calcium levels or signs of increased pressure in the brain.
How serious is the interaction between Tretinoin and Voriconazole?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Tretinoin and Voriconazole interact?
Voriconazole stops the body from breaking down tretinoin, which can lead to high levels of the drug in your blood.
Understanding the Tretinoin and Voriconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Tretinoin belongs to the Retinoid (Topical) class and Voriconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Voriconazole stops the body from breaking down tretinoin, which can lead to high levels of the drug in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Tretinoin has 3 total documented interactions on file in this dataset, and Voriconazole has 50. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should check you often for high calcium levels or signs of increased pressure in the brain. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Tretinoin or Voriconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.