fluvoxamine vs tizanidine
Side-by-side comparison of fluvoxamine and tizanidine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
( 7.2 , 12.3 ) 7.1 Strong CYP1A2 Inhibitors Concomitant use of tizanidine with strong cytochrome P450 1A2 (CYP1A2) inhibitors (e.g., fluvoxamine, ciprofloxacin) is contraindicated.
Recommendation: This combination should not be used. Your doctor will need to change one of your medications to a safer option.
Luvox
Zanaflex
Fluvoxamine is a medicine that can help treat obsessive compulsive disorder (OCD). It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Tizanidine is a muscle relaxant. It is used to treat spasticity, which is when your muscles are tight or stiff.
Fluvoxamine is used to treat obsessive compulsive disorder (OCD). OCD involves having constant, unwanted thoughts or behaviors that you feel the need to repeat. These thoughts or actions can cause you distress and interfere with your daily life.
Tizanidine is used to treat spasticity in adults. Spasticity is a condition where your muscles become stiff or tight. This medicine helps to relax your muscles and reduce the stiffness. It can help you move and feel more comfortable.
Fluvoxamine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluvoxamine can help reduce the symptoms of OCD.
Tizanidine works by affecting certain chemicals in your brain. It is an alpha-2 adrenergic agonist. This action helps to reduce muscle spasms and tightness.
- • Abnormal ejaculation
- • Loss of appetite
- • Problems having an orgasm
- • Weakness
- • Diarrhea
- • Dry mouth
- • Sleepiness
- • Weakness
- • Dizziness
- This medicine is interacting with another medicine 215
- Feeling sick to your stomach 117
- Sleepiness 114
- Feeling worried or nervous 103
- Thinking about suicide 96
- Tiredness 1,693
- Aches 1,615
- Feeling sick to your stomach 1,530
- Falling down 1,318
- Head pain 1,289
Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. Tell your doctor right away if you have any sudden changes in mood, behavior, thoughts, or feelings, especially if they are new, get worse, or worry you. Watch for suicidal thoughts or actions. Families and caregivers should also be aware of these risks.
Tizanidine can cause low blood pressure, liver problems, and hallucinations. It can also make you very sleepy, especially if you drink alcohol or take other medicines that cause sleepiness. Your doctor should check your liver function before you start taking tizanidine and one month after you reach your highest dose. Do not stop taking tizanidine suddenly, as this can cause withdrawal symptoms.
Tell your doctor if you are pregnant or plan to become pregnant. Fluvoxamine may cause problems for the baby if taken during pregnancy. Fluvoxamine can pass into breast milk and may harm a nursing baby.
Tizanidine may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if tizanidine passes into breast milk, so talk to your doctor if you are breastfeeding.
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How to Read This fluvoxamine vs tizanidine Comparison
fluvoxamine is classified in the Selective Serotonin Reuptake Inhibitor (SSRI) drug class, while tizanidine sits within the Central Alpha-2 Agonist (Muscle Relaxant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluvoxamine has 645 submissions while tizanidine has 7,445. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to fluvoxamine blocks the enzyme that normally clears tizanidine from your body. this leads to much higher amounts of tizanidine in your blood than intended.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between fluvoxamine and tizanidine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.