Theophylline and Bupropion Interaction
Drug interaction information between Theophylline and Bupropion.
Theophylline and Bupropion have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Theophylline and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can increase the risk of having a seizure. Taking them at the same time makes this risk even higher.
FDA Label Information
7.3 Drugs That Lower Seizure Threshold Use extreme caution when coadministering bupropion hydrochloride extended-release tablets (XL) with other drugs that lower the seizure threshold (e.g., other bupropion products, antipsychotics, antidepressants, theophylline, or systemic corticosteroids).
Theophylline Also Interacts With
- Metoprolol major
- Albuterol major
- Omeprazole major
- Amoxicillin major
- Famotidine major
Bupropion Also Interacts With
- Tranylcypromine major
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Theophylline + Bupropion?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Theophylline has 86 labeled pairs on file vs Bupropion's 35. In the moderate band specifically: Theophylline has 5 (also Clarithromycin, Febuxostat, Levofloxacin, Rifampin); Bupropion has 2 (also Isavuconazonium).
What mechanism field is on file for Theophylline and Bupropion?
Both of these medicines can increase the risk of having a seizure. Taking them at the same time makes this risk even higher.
Theophylline carries more major-labeled pairs than Bupropion
SPL source-record counts only. This page's band is moderate · classes on file: Theophylline (Methylxanthine Bronchodilator); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Theophylline has 27 major-labeled pairs vs Bupropion's 1. This page itself is in the moderate band, not the major band.
27 major · 5 moderate · 54 minor · 86 total
- Other moderate peers for Theophylline
- Clarithromycin
- Febuxostat
- Levofloxacin
- Rifampin
1 major · 2 moderate · 32 minor · 35 total
- Other moderate peers for Bupropion
- Isavuconazonium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.