Dicloxacillin and Warfarin Interaction
Drug interaction information between Dicloxacillin and Warfarin.
Dicloxacillin and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dicloxacillin and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dicloxacillin can make warfarin less effective at thinning the blood.
FDA Label Information
Dicloxacillin may reduce the anticoagulant response to dicumarol and warfarin.
Dicloxacillin Also Interacts With
- Tetracycline minor
- Probenecid minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Dicloxacillin + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Dicloxacillin's 3. In the minor band specifically: Dicloxacillin has 3 (also Tetracycline, Probenecid); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Dicloxacillin and Warfarin?
Dicloxacillin can make warfarin less effective at thinning the blood.
Warfarin carries more major-labeled pairs than Dicloxacillin
SPL source-record counts only. This page's band is minor · classes on file: Dicloxacillin (Penicillinase-Resistant Penicillin); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Dicloxacillin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Dicloxacillin
- Tetracycline
- Probenecid
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.