Dicloxacillin and Probenecid Interaction
Drug interaction information between Dicloxacillin and Probenecid.
Dicloxacillin and Probenecid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dicloxacillin and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid slows down how fast the body gets rid of dicloxacillin, causing the drug to stay in the blood longer.
FDA Label Information
Probenecid administered concomitantly with penicillins increases and prolongs serum penicillin levels (see DOSAGE AND ADMINISTRATION ).
Dicloxacillin Also Interacts With
- Warfarin minor
- Tetracycline minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Dicloxacillin + Probenecid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Dicloxacillin's 3. In the minor band specifically: Dicloxacillin has 3 (also Warfarin, Tetracycline); Probenecid has 23 (also Theophylline, Acetaminophen/Oxycodone, Ampicillin/Sulbactam, Carbidopa/Levodopa).
What mechanism field is on file for Dicloxacillin and Probenecid?
Probenecid slows down how fast the body gets rid of dicloxacillin, causing the drug to stay in the blood longer.
Probenecid carries more major-labeled pairs than Dicloxacillin
SPL source-record counts only. This page's band is minor · classes on file: Dicloxacillin (Penicillinase-Resistant Penicillin); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Dicloxacillin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 3 minor · 3 total
- Other minor peers for Dicloxacillin
- Warfarin
- Tetracycline
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Theophylline
- Acetaminophen/Oxycodone
- Ampicillin/Sulbactam
- Carbidopa/Levodopa
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.