Solifenacin and Darunavir Interaction
Drug interaction information between Solifenacin and Darunavir.
Solifenacin and Darunavir have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Solifenacin and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir slows down how quickly your body processes solifenacin, which increases the amount of the drug in your system.
FDA Label Information
solifenacin ↑ solifenacin When solifenacin is co-administered with darunavir/ritonavir, do not exceed a solifenacin dose of 5 mg once daily.
Solifenacin Also Interacts With
- Itraconazole major
- Ketoconazole minor
- Mirabegron minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Solifenacin + Darunavir?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Solifenacin's 4. In the major band specifically: Solifenacin has 2 (also Itraconazole); Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide).
What mechanism field is on file for Solifenacin and Darunavir?
Darunavir slows down how quickly your body processes solifenacin, which increases the amount of the drug in your system.
Darunavir carries more major-labeled pairs than Solifenacin
SPL source-record counts only. This page's band is major · classes on file: Solifenacin (Anticholinergic (Overactive Bladder)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Solifenacin's 2.
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.