What the FDA labels say about taking them together
Ketoconazole and solifenacin
Solifenacin's FDA label of February 4, 2026 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name solifenacin. The solifenacin label: “Concomitant use of ketoconazole, a strong CYP3A4 inhibitor, significantly increased the exposure of solifenacin.”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the solifenacin FDA label on DailyMed (effective February 4, 2026, Bostal LLC).
What does the ketoconazole label say about solifenacin?
Ketoconazole's label (effective January 28, 2026) does not name solifenacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the solifenacin label say about ketoconazole?
Solifenacin label, drug interactionsConcomitant use of ketoconazole, a strong CYP3A4 inhibitor, significantly increased the exposure of solifenacin [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Solifenacin Succinate), Bostal LLC, effective February 4, 2026 (SPL set d155c739-6870-4938-ba91-8c1b4b90afe4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Solifenacin | |
|---|---|---|
| Labeled for | Fungal infections | Overactive bladder |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $0.162 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once