amoxicillin vs probenecid
Side-by-side comparison of amoxicillin and probenecid. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7 DRUG INTERACTIONS Co‑administration with probenecid is not recommended. ( 7.4 ) 7.1 Probenecid Probenecid decreases the renal tubular secretion of amoxicillin but does not delay renal excretion of clavulanic acid. Co-administration of probenecid is not recommended.
Recommendation: This combination is not recommended, and you should talk to your doctor about using a different treatment plan.
Amoxil
Benemid
Amoxicillin and Clavulanate Potassium is a combination medicine used to fight bacterial infections. It contains amoxicillin, an antibiotic, and clavulanate, which helps the amoxicillin work better.
No summary available.
This medicine treats infections like lower respiratory infections, ear infections (otitis media), sinus infections, skin infections, and urinary tract infections. It works against specific bacteria that cause these infections. However, it should only be used when tests show the bacteria are susceptible to it, to avoid antibiotic resistance.
Information not available.
Amoxicillin kills bacteria by stopping them from building cell walls. Some bacteria produce a substance called beta-lactamase, which can destroy amoxicillin. Clavulanate blocks beta-lactamase, allowing amoxicillin to effectively kill the bacteria.
Information not available.
- • Diarrhea or loose stools
- • Nausea
- • Skin rashes
- • Hives
- • Vomiting
- • Diarrhea
- • Nausea
- • Yeast infection of the vagina
- • Headache
- • Vomiting
- Long-term kidney disease 4,661
- Sudden kidney damage 4,200
- Diarrhea 4,083
- Allergic reaction to the medicine 3,744
- Feeling sick to your stomach 3,700
- Diarrhea 76
- Difficulty breathing 52
- Adenovirus infection 47
- Weakness 47
- Tiredness 46
This medicine can cause serious allergic reactions, including fatal ones. Stop taking it and get medical help right away if you have any signs of an allergic reaction. This medicine can also cause severe skin reactions. Tell your doctor if you develop a rash. It can also cause liver problems and severe diarrhea.
No specific warnings noted.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. Amoxicillin passes into breast milk and may cause harm to a nursing infant. Talk to your doctor before breastfeeding.
No pregnancy information available.
How to Read This amoxicillin vs probenecid Comparison
amoxicillin is classified in the Penicillin Antibiotic drug class, while probenecid sits within the Uricosuric Agent class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amoxicillin has 20,388 submissions while probenecid has 268. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to probenecid blocks the kidneys from removing amoxicillin from the blood. this causes the antibiotic to stay in your body longer and reach higher levels than normal.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amoxicillin and probenecid - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.