Insulin Human and Olanzapine Interaction
Drug interaction information between Insulin Human and Olanzapine.
Insulin Human and Olanzapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Human and Olanzapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Olanzapine can make insulin less powerful, which may lead to higher blood sugar levels than usual.
FDA Label Information
Drugs that May Decrease the Blood Glucose Lowering Effect of HUMULIN 70/30 Drugs: Atypical antipsychotics (e.g., olanzapine and clozapine), corticosteroids, danazol, diuretics, estrogens, glucagon, isoniazid, niacin, oral contraceptives, phenothiazines, progestogens (e.g., in oral contraceptives), protease inhibitors, somatropin, sympathomimetic agents (e.g., albuterol, epinephrine, terbutaline), and thyroid hormones.
Insulin Human Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Clonidine minor
Olanzapine Also Interacts With
- Fluoxetine major
- Tetrabenazine moderate
- Omeprazole minor
- Warfarin minor
- Diazepam minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Human/Insulin Isophane + Olanzapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Olanzapine has 26 labeled pairs on file vs Insulin Human's 11. In the minor band specifically: Insulin Human has 8 (also Albuterol, Clonidine, Lithium, Clozapine); Olanzapine has 24 (also Omeprazole, Warfarin, Diazepam, Carbamazepine).
What mechanism field is on file for Insulin Human/Insulin Isophane and Olanzapine?
Olanzapine can make insulin less powerful, which may lead to higher blood sugar levels than usual.
Olanzapine carries more major-labeled pairs than Insulin Human
SPL source-record counts only. This page's band is minor · classes on file: Insulin Human (Intermediate-Acting Insulin Combination); Olanzapine (Atypical Antipsychotic).
Olanzapine has 1 major-labeled pair vs Insulin Human's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 8 minor · 11 total
1 major · 1 moderate · 24 minor · 26 total
- Other minor peers for Olanzapine
- Omeprazole
- Warfarin
- Diazepam
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.