Insulin Human and Clonidine Interaction
Drug interaction information between Insulin Human and Clonidine.
Insulin Human and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Human and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clonidine can change how well insulin works and hide the normal warning signs of low blood sugar, such as a fast heartbeat.
FDA Label Information
Drugs that May Increase or Decrease the Blood Glucose Lowering Effect of HUMULIN 70/30 Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs that May Blunt Signs and Symptoms of Hypoglycemia Drugs: Beta-blockers, clonidine, guanethidine, and reserpine Intervention: Increased frequency of glucose monitoring may be required when HUMULIN 70/30 is co-administered with these drugs. ( 7 ) Antiadrenergic Drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine): Signs and symptoms of hypoglycemia may be reduced or absent.
Insulin Human Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Olanzapine minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Insulin Human/Insulin Isophane + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Insulin Human's 11. In the minor band specifically: Insulin Human has 8 (also Albuterol, Olanzapine, Lithium, Clozapine); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Insulin Human/Insulin Isophane and Clonidine?
Clonidine can change how well insulin works and hide the normal warning signs of low blood sugar, such as a fast heartbeat.
Clonidine's labeled portfolio outnumbers Insulin Human
SPL source-record counts only. This page's band is minor · classes on file: Insulin Human (Intermediate-Acting Insulin Combination); Clonidine (Central Alpha-2 Agonist).
0 major · 3 moderate · 8 minor · 11 total
- Other minor peers for Insulin Human
- Albuterol
- Olanzapine
- Lithium
- Clozapine
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.