Insulin Human/Insulin Isophane and Clonidine Interaction
Drug interaction information between Insulin Human/Insulin Isophane and Clonidine.
Insulin Human/Insulin Isophane and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Insulin Human/Insulin Isophane and Clonidine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Clonidine can change how well insulin works and hide the normal warning signs of low blood sugar, such as a fast heartbeat.
What To Do
You should check your blood sugar levels more often when taking these two medicines together.
FDA Label Information
Drugs that May Increase or Decrease the Blood Glucose Lowering Effect of HUMULIN 70/30 Drugs: Alcohol, beta-blockers, clonidine, and lithium salts. Drugs that May Blunt Signs and Symptoms of Hypoglycemia Drugs: Beta-blockers, clonidine, guanethidine, and reserpine Intervention: Increased frequency of glucose monitoring may be required when HUMULIN 70/30 is co-administered with these drugs. ( 7 ) Antiadrenergic Drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine): Signs and symptoms of hypoglycemia may be reduced or absent.
Insulin Human/Insulin Isophane Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Octreotide moderate
- Albuterol minor
- Olanzapine minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
Can I take Insulin Human/Insulin Isophane and Clonidine together?
This is a minor interaction. You should check your blood sugar levels more often when taking these two medicines together.
How serious is the interaction between Insulin Human/Insulin Isophane and Clonidine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Insulin Human/Insulin Isophane and Clonidine interact?
Clonidine can change how well insulin works and hide the normal warning signs of low blood sugar, such as a fast heartbeat.
Understanding the Insulin Human/Insulin Isophane and Clonidine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Insulin Human/Insulin Isophane belongs to the Intermediate-Acting Insulin Combination class and Clonidine belongs to the Central Alpha-2 Agonist class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Clonidine can change how well insulin works and hide the normal warning signs of low blood sugar, such as a fast heartbeat. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Insulin Human/Insulin Isophane has 11 total documented interactions on file in this dataset, and Clonidine has 29. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should check your blood sugar levels more often when taking these two medicines together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Insulin Human/Insulin Isophane or Clonidine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.