Insulin Human and Octreotide Interaction
Drug interaction information between Insulin Human and Octreotide.
Insulin Human and Octreotide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Insulin Human and Octreotide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Octreotide can lower blood sugar levels, which adds to the effect of insulin and makes low blood sugar more likely.
FDA Label Information
7 DRUG INTERACTIONS Table 1: Clinically Significant Drug Interactions with HUMULIN 70/30 Drugs that May Increase the Risk of Hypoglycemia Drugs: Antidiabetic agents, ACE inhibitors, angiotensin II receptor blocking agents, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, pramlintide, salicylates, somatostatin analog (e.g., octreotide), and sulfonamide antibiotics Intervention: Dose adjustment and increased frequency of glucose monitoring may be required when HUMULIN 70/30 is co-administered with these drugs.
Insulin Human Also Interacts With
- Fluoxetine moderate
- Pramlintide moderate
- Albuterol minor
- Clonidine minor
- Olanzapine minor
Octreotide Also Interacts With
- Insulin Aspart moderate
- Insulin Degludec moderate
- Insulin Detemir moderate
- Insulin Glargine moderate
- Insulin Glulisine moderate
Frequently Asked Questions
What SPL severity band is on file for Insulin Human/Insulin Isophane + Octreotide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Octreotide has 14 labeled pairs on file vs Insulin Human's 11. In the moderate band specifically: Insulin Human has 3 (also Fluoxetine, Pramlintide); Octreotide has 9 (also Insulin Aspart, Insulin Degludec, Insulin Detemir, Insulin Glargine).
What mechanism field is on file for Insulin Human/Insulin Isophane and Octreotide?
Octreotide can lower blood sugar levels, which adds to the effect of insulin and makes low blood sugar more likely.
Octreotide's labeled portfolio outnumbers Insulin Human
SPL source-record counts only. This page's band is moderate · classes on file: Insulin Human (Intermediate-Acting Insulin Combination); Octreotide (Somatostatin Analog).
0 major · 3 moderate · 8 minor · 11 total
- Other moderate peers for Insulin Human
- Fluoxetine
- Pramlintide
0 major · 9 moderate · 5 minor · 14 total
- Other moderate peers for Octreotide
- Insulin Aspart
- Insulin Degludec
- Insulin Detemir
- Insulin Glargine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.