Pindolol and Thioridazine Interaction
Drug interaction information between Pindolol and Thioridazine.
Pindolol and Thioridazine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pindolol and Thioridazine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs block each other from being cleared out of your system. This leads to higher levels of both drugs in your blood than your doctor intended.
What To Do
You should not take these two medications at the same time. Ask your doctor for a safer combination of medicines.
FDA Label Information
Drug Interactions Reduced cytochrome P450 2D6 isozyme activity, drugs which inhibit this isozyme (e.g., fluoxetine and paroxetine), and certain other drugs (e.g., fluvoxamine, propranolol, and pindolol) appear to appreciably inhibit the metabolism of thioridazine. Pindolol Concurrent administration of pindolol and thioridazine have resulted in moderate, dose related increases in the serum levels of thioridazine and two of its metabolites, as well as higher than expected serum pindolol levels. Pindolol and thioridazine should not be coadministered.
Pindolol Also Interacts With
- Hydrochlorothiazide minor
- Hydralazine minor
- Epinephrine minor
Thioridazine Also Interacts With
- Fluoxetine major
- Paroxetine major
- Rolapitant major
- Abiraterone moderate
- Darifenacin moderate
Frequently Asked Questions
Can I take Pindolol and Thioridazine together?
This is a minor interaction. You should not take these two medications at the same time. Ask your doctor for a safer combination of medicines.
How serious is the interaction between Pindolol and Thioridazine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Pindolol and Thioridazine interact?
These two drugs block each other from being cleared out of your system. This leads to higher levels of both drugs in your blood than your doctor intended.
Understanding the Pindolol and Thioridazine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Pindolol belongs to the Beta-Blocker with ISA class and Thioridazine belongs to the Typical Antipsychotic (Phenothiazine) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs block each other from being cleared out of your system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Pindolol has 4 total documented interactions on file in this dataset, and Thioridazine has 17. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should not take these two medications at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Pindolol or Thioridazine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.