Pindolol and Thioridazine Interaction
Drug interaction information between Pindolol and Thioridazine.
Pindolol and Thioridazine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pindolol and Thioridazine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs block each other from being cleared out of your system. This leads to higher levels of both drugs in your blood than your doctor intended.
FDA Label Information
Drug Interactions Reduced cytochrome P450 2D6 isozyme activity, drugs which inhibit this isozyme (e.g., fluoxetine and paroxetine), and certain other drugs (e.g., fluvoxamine, propranolol, and pindolol) appear to appreciably inhibit the metabolism of thioridazine. Pindolol Concurrent administration of pindolol and thioridazine have resulted in moderate, dose related increases in the serum levels of thioridazine and two of its metabolites, as well as higher than expected serum pindolol levels. Pindolol and thioridazine should not be coadministered.
Pindolol Also Interacts With
- Hydrochlorothiazide minor
- Hydralazine minor
- Epinephrine minor
Thioridazine Also Interacts With
- Fluoxetine major
- Paroxetine major
- Rolapitant major
- Abiraterone moderate
- Darifenacin moderate
Frequently Asked Questions
What SPL severity band is on file for Pindolol + Thioridazine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Thioridazine has 17 labeled pairs on file vs Pindolol's 4. In the minor band specifically: Pindolol has 4 (also Hydrochlorothiazide, Hydralazine, Epinephrine); Thioridazine has 11 (also Propranolol, Bupropion, Carbamazepine, Clozapine).
What mechanism field is on file for Pindolol and Thioridazine?
These two drugs block each other from being cleared out of your system. This leads to higher levels of both drugs in your blood than your doctor intended.
Thioridazine carries more major-labeled pairs than Pindolol
SPL source-record counts only. This page's band is minor · classes on file: Pindolol (Beta-Blocker with ISA); Thioridazine (Typical Antipsychotic (Phenothiazine)).
Thioridazine has 3 major-labeled pairs vs Pindolol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Pindolol
- Hydrochlorothiazide
- Hydralazine
- Epinephrine
3 major · 3 moderate · 11 minor · 17 total
- Other minor peers for Thioridazine
- Propranolol
- Bupropion
- Carbamazepine
- Clozapine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.