Pindolol and Epinephrine Interaction
Drug interaction information between Pindolol and Epinephrine.
Pindolol and Epinephrine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pindolol and Epinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Pindolol can block the action of epinephrine, which is used to treat severe allergic reactions. This means the usual dose of epinephrine might not work as well as it should.
FDA Label Information
Such patients may be unresponsive to the usual doses of epinephrine used to treat allergic reactions.
Pindolol Also Interacts With
- Hydrochlorothiazide minor
- Hydralazine minor
- Thioridazine minor
Epinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
Frequently Asked Questions
What SPL severity band is on file for Pindolol + Epinephrine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Epinephrine has 28 labeled pairs on file vs Pindolol's 4. In the minor band specifically: Pindolol has 4 (also Hydrochlorothiazide, Hydralazine, Thioridazine); Epinephrine has 24 (also Levothyroxine, Clonidine, Theophylline, Oxytocin).
What mechanism field is on file for Pindolol and Epinephrine?
Pindolol can block the action of epinephrine, which is used to treat severe allergic reactions. This means the usual dose of epinephrine might not work as well as it should.
Epinephrine carries more major-labeled pairs than Pindolol
SPL source-record counts only. This page's band is minor · classes on file: Pindolol (Beta-Blocker with ISA); Epinephrine (Adrenergic Agonist).
Epinephrine has 1 major-labeled pair vs Pindolol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Pindolol
- Hydrochlorothiazide
- Hydralazine
- Thioridazine
1 major · 3 moderate · 24 minor · 28 total
- Other minor peers for Epinephrine
- Levothyroxine
- Clonidine
- Theophylline
- Oxytocin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.