pindolol vs thioridazine
Side-by-side comparison of pindolol and thioridazine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drug Interactions Reduced cytochrome P450 2D6 isozyme activity, drugs which inhibit this isozyme (e.g., fluoxetine and paroxetine), and certain other drugs (e.g., fluvoxamine, propranolol, and pindolol) appear to appreciably inhibit the metabolism of thioridazine. Pindolol Concurrent administration of pindolol and thioridazine have resulted in moderate, dose related increases in the serum levels of thioridazine and two of its metabolites, as well as higher than expected serum pindolol levels. Pindolol and thioridazine should not be coadministered.
Recommendation: You should not take these two medications at the same time. Ask your doctor for a safer combination of medicines.
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Mellaril
Pindolol is a medicine that lowers high blood pressure. It belongs to a class of drugs called beta-blockers.
Thioridazine is a medicine used to treat schizophrenia. It is only used when other antipsychotic medicines have not worked well enough.
Pindolol treats high blood pressure. You can take it alone or with other blood pressure medicines. It often works well when combined with a water pill (diuretic).
Thioridazine is used to manage schizophrenia in adults and children. You should only use this medicine if other antipsychotic medicines have not worked for you. This is because thioridazine can cause serious heart problems.
Pindolol blocks the effects of certain natural chemicals in your body, like adrenaline. This helps to slow down your heart rate and lower your blood pressure. It also has some stimulating activity of its own.
Thioridazine affects the balance of certain chemicals in the brain. These chemicals, like dopamine, can affect mood and behavior. By changing the balance, thioridazine helps to reduce symptoms of schizophrenia.
- • Bizarre or many dreams
- • Dizziness
- • Fatigue
- • Insomnia
- • Nervousness
- • Drowsiness
- • Dry mouth
- • Blurred vision
- • Constipation
- • Nausea
- Feeling tired 43
- Feeling sick to your stomach 43
- Bladder infection 42
- Feeling lightheaded 41
- The medicine is interacting with another medicine 40
- Weight gain 8
- Shortness of breath 7
- Muscle spasms and contractions 6
- High blood sugar 6
- Low oxygen levels 6
You should not take pindolol if you have asthma, heart failure, cardiogenic shock, second or third-degree heart block, or a very slow heart rate.
Thioridazine can cause a life-threatening heart rhythm problem called Torsades de pointes, which can lead to sudden death. Because of this risk, only use thioridazine if other antipsychotic medicines have not worked. Elderly patients with dementia-related psychosis who are treated with antipsychotic drugs have an increased risk of death.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if pindolol will harm your unborn baby. Talk to your doctor about the risks and benefits of taking pindolol while breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if thioridazine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking thioridazine during pregnancy and breastfeeding.
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How to Read This pindolol vs thioridazine Comparison
pindolol is classified in the Beta-Blocker with ISA drug class, while thioridazine sits within the Typical Antipsychotic (Phenothiazine) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, pindolol has 209 submissions while thioridazine has 33. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these two drugs block each other from being cleared out of your system. this leads to higher levels of both drugs in your blood than your doctor intended.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between pindolol and thioridazine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.