Pindolol and Hydralazine Interaction
Drug interaction information between Pindolol and Hydralazine.
Pindolol and Hydralazine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pindolol and Hydralazine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two blood pressure medicines can be used together safely. They do not have any harmful interactions when taken at the same time.
What To Do
You can take these medications together as prescribed. Your doctor will monitor your blood pressure to ensure the treatment is working.
FDA Label Information
Pindolol has been used with a variety of antihypertensive agents, including hydrochlorothiazide, hydralazine, and guanethidine without unexpected adverse interactions.
Pindolol Also Interacts With
- Hydrochlorothiazide minor
- Epinephrine minor
- Thioridazine minor
Frequently Asked Questions
Can I take Pindolol and Hydralazine together?
This is a minor interaction. You can take these medications together as prescribed. Your doctor will monitor your blood pressure to ensure the treatment is working.
How serious is the interaction between Pindolol and Hydralazine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Pindolol and Hydralazine interact?
These two blood pressure medicines can be used together safely. They do not have any harmful interactions when taken at the same time.
Understanding the Pindolol and Hydralazine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Pindolol belongs to the Beta-Blocker with ISA class and Hydralazine belongs to the Vasodilator class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two blood pressure medicines can be used together safely. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Pindolol has 4 total documented interactions on file in this dataset, and Hydralazine has 3. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can take these medications together as prescribed. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Pindolol or Hydralazine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.