Pindolol and Hydrochlorothiazide Interaction
Drug interaction information between Pindolol and Hydrochlorothiazide.
Pindolol and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pindolol and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs are often used together to lower blood pressure without causing any unexpected problems. They work in different ways to help your heart and blood vessels.
FDA Label Information
Pindolol has been used with a variety of antihypertensive agents, including hydrochlorothiazide, hydralazine, and guanethidine without unexpected adverse interactions.
Pindolol Also Interacts With
- Hydralazine minor
- Epinephrine minor
- Thioridazine minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
What SPL severity band is on file for Pindolol + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Pindolol's 4. In the minor band specifically: Pindolol has 4 (also Hydralazine, Epinephrine, Thioridazine); Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Pindolol and Hydrochlorothiazide?
These drugs are often used together to lower blood pressure without causing any unexpected problems. They work in different ways to help your heart and blood vessels.
Hydrochlorothiazide carries more major-labeled pairs than Pindolol
SPL source-record counts only. This page's band is minor · classes on file: Pindolol (Beta-Blocker with ISA); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Pindolol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 4 minor · 4 total
- Other minor peers for Pindolol
- Hydralazine
- Epinephrine
- Thioridazine
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.