Ofloxacin and Sucralfate Interaction
Drug interaction information between Ofloxacin and Sucralfate.
Ofloxacin and Sucralfate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ofloxacin and Sucralfate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sucralfate interferes with how your body absorbs ofloxacin, which can stop the antibiotic from working correctly.
FDA Label Information
In all case studies to date (cimetidine, ciprofloxacin, digoxin, norfloxacin, ofloxacin, and ranitidine), dosing the concomitant medication 2 hours before sucralfate eliminated the interaction.
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Warfarin minor
- Ketoconazole minor
- Ciprofloxacin minor
Frequently Asked Questions
What SPL severity band is on file for Ofloxacin + Sucralfate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sucralfate has 20 labeled pairs on file vs Ofloxacin's 2. In the minor band specifically: Ofloxacin has 1; Sucralfate has 18 (also Warfarin, Ketoconazole, Ciprofloxacin, Tetracycline).
What mechanism field is on file for Ofloxacin and Sucralfate?
Sucralfate interferes with how your body absorbs ofloxacin, which can stop the antibiotic from working correctly.
Sucralfate's labeled portfolio outnumbers Ofloxacin
SPL source-record counts only. This page's band is minor · classes on file: Ofloxacin (Fluoroquinolone Antibiotic); Sucralfate (Mucosal Protective Agent).
1 major · 0 moderate · 1 minor · 2 total
Ofloxacin has no other minor-band peer in this dataset besides Sucralfate.
1 major · 1 moderate · 18 minor · 20 total
- Other minor peers for Sucralfate
- Warfarin
- Ketoconazole
- Ciprofloxacin
- Tetracycline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.