Sucralfate and Tetracycline Interaction
Drug interaction information between Sucralfate and Tetracycline.
Sucralfate and Tetracycline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sucralfate and Tetracycline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sucralfate can block your body from absorbing tetracycline if they are taken together. This could prevent the antibiotic from treating your infection effectively.
FDA Label Information
Drug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline.
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Warfarin minor
- Ketoconazole minor
- Ciprofloxacin minor
Tetracycline Also Interacts With
- Theophylline major
- Doxycycline moderate
- Doxycycline Hyclate moderate
- Minocycline moderate
- Zinc Sulfate minor
Frequently Asked Questions
What SPL severity band is on file for Sucralfate + Tetracycline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sucralfate has 20 labeled pairs on file vs Tetracycline's 12. In the minor band specifically: Sucralfate has 18 (also Warfarin, Ketoconazole, Ciprofloxacin, Ofloxacin); Tetracycline has 8 (also Zinc Sulfate, Atovaquone/Proguanil, Cholestyramine, Colestipol).
What mechanism field is on file for Sucralfate and Tetracycline?
Sucralfate can block your body from absorbing tetracycline if they are taken together. This could prevent the antibiotic from treating your infection effectively.
Sucralfate's labeled portfolio outnumbers Tetracycline
SPL source-record counts only. This page's band is minor · classes on file: Sucralfate (Mucosal Protective Agent); Tetracycline (Tetracycline Antibiotic).
1 major · 1 moderate · 18 minor · 20 total
- Other minor peers for Sucralfate
- Warfarin
- Ketoconazole
- Ciprofloxacin
- Ofloxacin
1 major · 3 moderate · 8 minor · 12 total
- Other minor peers for Tetracycline
- Zinc Sulfate
- Atovaquone/Proguanil
- Cholestyramine
- Colestipol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.