What the FDA labels say about taking them together
Sucralfate and tetracycline
Sucralfate's FDA label of September 2, 2026 names tetracycline in its drug interactions section; the tetracycline label PlainMeds reads does not name sucralfate. The sucralfate label: “… antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline.”
Check it at the source: the sucralfate FDA label on DailyMed (effective September 2, 2026, Preferred Pharmaceuticals Inc.); the tetracycline FDA label on DailyMed (effective March 18, 2025, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.).
What does the sucralfate label say about tetracycline?
Sucralfate label, drug interactionsDrug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline.
Source: FDA drug label (Sucralfate), NDA018333 (Abbvie), as published by Preferred Pharmaceuticals Inc., effective September 2, 2026 (SPL set 536b8c00-13ab-4397-a754-63a1c92bf883), via openFDA; the full label on DailyMed
What does the tetracycline label say about sucralfate?
Tetracycline's label (effective March 18, 2025) does not name sucralfate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (tetracycline hydrochloride), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective March 18, 2025 (SPL set eaa5b1bd-0927-46e4-b941-32fcc492d258), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sucralfate | Tetracycline | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Bacterial infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.173 per tablet 1 g tablet | $0.247 per capsule 250 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once