Nirmatrelvir/Ritonavir and Colchicine Interaction

Drug interaction information between Nirmatrelvir/Ritonavir and Colchicine.

Nirmatrelvir/Ritonavir and Colchicine have a documented major interaction in FDA labeling.

FDA drug labeling documents a major-severity interaction between Nirmatrelvir/Ritonavir and Colchicine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Nirmatrelvir/Ritonavir

Antiviral (Protease Inhibitor Combination)

Drug B

Colchicine

Anti-Gout Agent

How They Interact

Ritonavir stops the body from processing colchicine, which can cause the drug to reach toxic levels. This is very dangerous and can be life-threatening, especially for people with liver or kidney disease.

FDA Label Information

Anti-gout colchicine ↑ colchicine Co-administration contraindicated due to potential for serious and/or life-threatening reactions in patients with renal and/or hepatic impairment [see Contraindications (4) ] .

Frequently Asked Questions

What SPL severity band is on file for Nirmatrelvir/Ritonavir + Colchicine?

Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Colchicine's 28. In the major band specifically: Nirmatrelvir/Ritonavir has 23 (also Simvastatin, Lovastatin, Sildenafil, Carbamazepine); Colchicine has 4 (also Clarithromycin, Darunavir, Itraconazole).

What mechanism field is on file for Nirmatrelvir/Ritonavir and Colchicine?

Ritonavir stops the body from processing colchicine, which can cause the drug to reach toxic levels. This is very dangerous and can be life-threatening, especially for people with liver or kidney disease.

Nirmatrelvir/Ritonavir carries more major-labeled pairs than Colchicine

SPL source-record counts only. This page's band is major · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Colchicine (Anti-Gout Agent).

Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Colchicine's 4.

Nirmatrelvir/Ritonavir

23 major · 30 moderate · 33 minor · 86 total

Colchicine

4 major · 9 moderate · 15 minor · 28 total

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.