Nalbuphine and Phenelzine Interaction
Drug interaction information between Nalbuphine and Phenelzine.
Nalbuphine and Phenelzine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nalbuphine and Phenelzine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can cause serotonin levels to become dangerously high or make the opioid effects much stronger. This can lead to serious breathing problems or a condition called serotonin syndrome.
FDA Label Information
Monoamine Oxidase Inhibitors (MAOIs) MAOI (e.g., phenelzine, tranylcypromine, linezolid) interactions with opioids may manifest as serotonin syndrome [see Drug Interactions ] or opioid toxicity (e.g., respiratory depression, coma [see WARNINGS ]).
Nalbuphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Linezolid minor
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Frequently Asked Questions
What SPL severity band is on file for Nalbuphine + Phenelzine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Nalbuphine's 19. In the minor band specifically: Nalbuphine has 18 (also Trazodone, Cyclobenzaprine, Mirtazapine, Linezolid); Phenelzine has 16 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Nalbuphine and Phenelzine?
Combining these drugs can cause serotonin levels to become dangerously high or make the opioid effects much stronger. This can lead to serious breathing problems or a condition called serotonin syndrome.
Phenelzine's labeled portfolio outnumbers Nalbuphine
SPL source-record counts only. This page's band is minor · classes on file: Nalbuphine (Opioid Agonist-Antagonist); Phenelzine (Monoamine Oxidase Inhibitor (MAOI)).
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Nalbuphine
- Trazodone
- Cyclobenzaprine
- Mirtazapine
- Linezolid
0 major · 11 moderate · 16 minor · 27 total
- Other minor peers for Phenelzine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.