Nalbuphine and Cyclobenzaprine Interaction
Drug interaction information between Nalbuphine and Cyclobenzaprine.
Nalbuphine and Cyclobenzaprine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nalbuphine and Cyclobenzaprine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both affect the serotonin system in your brain. Using them together increases the risk of having too much serotonin in your body at once.
FDA Label Information
Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), and monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and...
Nalbuphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Mirtazapine minor
- Linezolid minor
- Phenelzine minor
Cyclobenzaprine Also Interacts With
- Clozapine moderate
- Tapentadol moderate
- Tranylcypromine moderate
- Acetaminophen/Oxycodone minor
- Buprenorphine minor
Frequently Asked Questions
What SPL severity band is on file for Nalbuphine + Cyclobenzaprine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nalbuphine has 19 labeled pairs on file vs Cyclobenzaprine's 17. In the minor band specifically: Nalbuphine has 18 (also Trazodone, Mirtazapine, Linezolid, Phenelzine); Cyclobenzaprine has 14 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Nalbuphine and Cyclobenzaprine?
These medications both affect the serotonin system in your brain. Using them together increases the risk of having too much serotonin in your body at once.
Nalbuphine's labeled portfolio outnumbers Cyclobenzaprine
SPL source-record counts only. This page's band is minor · classes on file: Nalbuphine (Opioid Agonist-Antagonist); Cyclobenzaprine (Muscle Relaxant).
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Nalbuphine
- Trazodone
- Mirtazapine
- Linezolid
- Phenelzine
0 major · 3 moderate · 14 minor · 17 total
- Other minor peers for Cyclobenzaprine
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.