Nalbuphine and Mirtazapine Interaction
Drug interaction information between Nalbuphine and Mirtazapine.
Nalbuphine and Mirtazapine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Nalbuphine and Mirtazapine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can cause serotonin levels to rise too high because both medications influence the same pathways in your nervous system.
FDA Label Information
Serotonergic Drugs The concomitant use of opioids with other drugs that affect the serotonergic neurotransmitter system, such as selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), and monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and...
Nalbuphine Also Interacts With
- Oxycodone moderate
- Trazodone minor
- Cyclobenzaprine minor
- Linezolid minor
- Phenelzine minor
Mirtazapine Also Interacts With
- Linezolid major
- Alprazolam moderate
- Diazepam moderate
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Nalbuphine + Mirtazapine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Mirtazapine has 29 labeled pairs on file vs Nalbuphine's 19. In the minor band specifically: Nalbuphine has 18 (also Trazodone, Cyclobenzaprine, Linezolid, Phenelzine); Mirtazapine has 23 (also Buspirone, Warfarin, Carbamazepine, Lithium).
What mechanism field is on file for Nalbuphine and Mirtazapine?
Combining these drugs can cause serotonin levels to rise too high because both medications influence the same pathways in your nervous system.
Mirtazapine carries more major-labeled pairs than Nalbuphine
SPL source-record counts only. This page's band is minor · classes on file: Nalbuphine (Opioid Agonist-Antagonist); Mirtazapine (Noradrenergic and Specific Serotonergic Antidepressant (NaSSA)).
Mirtazapine has 1 major-labeled pair vs Nalbuphine's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Nalbuphine
- Trazodone
- Cyclobenzaprine
- Linezolid
- Phenelzine
1 major · 5 moderate · 23 minor · 29 total
- Other minor peers for Mirtazapine
- Buspirone
- Warfarin
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.