Ketorolac and Probenecid Interaction
Drug interaction information between Ketorolac and Probenecid.
Ketorolac and Probenecid have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ketorolac and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid slows down the body's ability to clear ketorolac, which leads to much higher and potentially unsafe levels of the drug in your system.
FDA Label Information
Established and Other Potentially Clinically Significant Drug Interactions Concomitant Drug/Drug Class Effect on Drug Concentration Recommendation Ketorolac tromethamine ↑ ketorolac tromethamine Contraindicated Ketoprofen ↑ ketoprofen Concomitant use is not recommended.
Probenecid Also Interacts With
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
- Cefuroxime moderate
Frequently Asked Questions
What SPL severity band is on file for Ketorolac + Probenecid?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Ketorolac's 3. In the major band specifically: Ketorolac has 1; Probenecid has 2 (also Levofloxacin).
What mechanism field is on file for Ketorolac and Probenecid?
Probenecid slows down the body's ability to clear ketorolac, which leads to much higher and potentially unsafe levels of the drug in your system.
Probenecid carries more major-labeled pairs than Ketorolac
SPL source-record counts only. This page's band is major · classes on file: Ketorolac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Ketorolac's 1.
1 major · 1 moderate · 1 minor · 3 total
Ketorolac has no other major-band peer in this dataset besides Probenecid.
2 major · 12 moderate · 23 minor · 37 total
- Other major peers for Probenecid
- Levofloxacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.