Ketorolac and Warfarin Interaction
Drug interaction information between Ketorolac and Warfarin.
Ketorolac and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ketorolac and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs interfere with how your blood clots, which increases the risk of bleeding. Taking them together creates an additive effect that makes it harder for your body to stop a bleed.
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Ketorolac + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Ketorolac's 3. In the moderate band specifically: Ketorolac has 1; Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Desvenlafaxine).
What mechanism field is on file for Ketorolac and Warfarin?
Both drugs interfere with how your blood clots, which increases the risk of bleeding. Taking them together creates an additive effect that makes it harder for your body to stop a bleed.
Warfarin carries more major-labeled pairs than Ketorolac
SPL source-record counts only. This page's band is moderate · classes on file: Ketorolac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Ketorolac's 1. This page itself is in the moderate band, not the major band.
1 major · 1 moderate · 1 minor · 3 total
Ketorolac has no other moderate-band peer in this dataset besides Warfarin.
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.