Ketorolac and Enoxaparin Interaction
Drug interaction information between Ketorolac and Enoxaparin.
Ketorolac and Enoxaparin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ketorolac and Enoxaparin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs affect how your blood clots, and taking them together increases your risk of serious bleeding.
What To Do
Use this combination with caution and tell your doctor immediately if you notice any unusual bruising or bleeding.
FDA Label Information
These agents include medications such as: anticoagulants, platelet inhibitors including acetylsalicylic acid, salicylates, NSAIDs (including ketorolac tromethamine), dipyridamole, or sulfinpyrazone.
Enoxaparin Also Interacts With
- Rivaroxaban moderate
- Dipyridamole minor
Frequently Asked Questions
Can I take Ketorolac and Enoxaparin together?
This is a minor interaction. Use this combination with caution and tell your doctor immediately if you notice any unusual bruising or bleeding.
How serious is the interaction between Ketorolac and Enoxaparin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Ketorolac and Enoxaparin interact?
Both drugs affect how your blood clots, and taking them together increases your risk of serious bleeding.
Understanding the Ketorolac and Enoxaparin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Ketorolac belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class and Enoxaparin belongs to the Low-Molecular-Weight Heparin class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs affect how your blood clots, and taking them together increases your risk of serious bleeding. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ketorolac has 3 total documented interactions on file in this dataset, and Enoxaparin has 3. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use this combination with caution and tell your doctor immediately if you notice any unusual bruising or bleeding. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ketorolac or Enoxaparin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.