What the FDA labels say about taking them together
Piperacillin/tazobactam and vancomycin
Piperacillin/tazobactam's FDA label of July 21, 2025 names vancomycin in its drug interactions section, and vancomycin's label names piperacillin/tazobactam too. The piperacillin/tazobactam label: “Co-administration of ZOSYN with vancomycin may increase the incidence of acute kidney injury.”
Check it at the source: the piperacillin/tazobactam FDA label on DailyMed (effective July 21, 2025, ONESOURCE SPECIALTY PHARMA LIMITED); the vancomycin FDA label on DailyMed (effective June 7, 2024, Mylan Institutional LLC).
What does the piperacillin/tazobactam label say about vancomycin?
Piperacillin/tazobactam label, drug interactionsMonitor tobramycin concentrations in these patients. ( 7.1 ) Probenecid prolongs the half-lives of piperacillin and tazobactam and should not be co-administered with piperacillin and tazobactam unless the benefit outweighs the risk. ( 7.2 ) Co-administration of piperacillin and tazobactam with vancomycin may increase the incidence of acute kidney injury.
Piperacillin/tazobactam label, warnings and precautionsCombined use of piperacillin and tazobactam and vancomycin may be associated with an increased incidence of acute kidney injury [see Drug Interactions (7.3) ].
Zosyn label (Baxter Healthcare Corporation, May 15, 2026), drug interactionsCo-administration of ZOSYN with vancomycin may increase the incidence of acute kidney injury.
Source: FDA drug label (Zosyn, NDA050750), Baxter Healthcare Corporation, effective May 15, 2026 (SPL set 8db6bd91-2106-4bfd-8cc8-38aaf1e18d17), via openFDA
Source: FDA drug label (Piperacillin And Tazobactam And Sodium Chloride, NDA206056), B. Braun Medical Inc., effective May 8, 2026 (SPL set a63ca653-27d4-45fe-a744-77e0efe45220), via openFDA
Source: FDA drug label (piperacillin and tazobactam), ONESOURCE SPECIALTY PHARMA LIMITED, effective July 21, 2025 (SPL set 28258745-12e4-4f0f-b318-4a1a1bebc928), via openFDA; the full label on DailyMed
What does the vancomycin label say about piperacillin/tazobactam?
Vancomycin label, drug interactionsPiperacillin/Tazobactam: Increased incidence of acute kidney injury in patients receiving concomitant piperacillin/tazobactam and vancomycin as compared to vancomycin alone. Monitor kidney function in patients
Source: FDA drug label (Tyzavan, NDA211962), Hikma Pharmaceuticals USA Inc., effective August 19, 2026 (SPL set 72e9c5e2-07cc-4a8b-ba64-b2e7619ea560), via openFDA
Source: FDA drug label (Vancomycin Hydrochloride, NDA210274), HIKMA PHARMACEUTICALS USA INC., effective August 13, 2025 (SPL set 8eccafe8-40c9-495a-872d-7f45a98ee759), via openFDA
Source: FDA drug label (Vancomycin Hydrochloride), Mylan Institutional LLC, effective June 7, 2024 (SPL set caf22ccb-df75-45ea-a1d0-ccb2d37272fb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Piperacillin/tazobactam | Vancomycin | |
|---|---|---|
| Labeled for | Bacterial infections | Bacterial infections, Diarrhea |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $3.49 per vial 3.375 g vial | $1.33 per capsule 125 mg capsule |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once