Formoterol and Budesonide/Formoterol Interaction
Drug interaction information between Formoterol and Budesonide/Formoterol.
Formoterol and Budesonide/Formoterol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Formoterol and Budesonide/Formoterol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines can work together to increase the effects of formoterol on your heart and blood vessels. This can lead to changes in your heart rate or blood pressure.
FDA Label Information
May potentiate effect of formoterol on vascular system. 7.2 Monoamine Oxidase Inhibitors and Tricyclic Antidepressants SYMBICORT should be administered with caution to patients being treated with monoamine oxidase inhibitors or tricyclic antidepressants, or within 2 weeks of discontinuation of such agents, because the action of formoterol, a component of SYMBICORT, on the vascular system may be potentiated by these agents. 7.3 Beta-Adrenergic Receptor Blocking Agents Beta-blockers (including eye drops) may not only block the pulmonary effect of beta-agonists, such as formoterol, a...
Formoterol Also Interacts With
- Aclidinium moderate
- Glycopyrrolate/Formoterol moderate
Budesonide/Formoterol Also Interacts With
- Ketoconazole moderate
- Clarithromycin moderate
- Itraconazole moderate
- Budesonide minor
Frequently Asked Questions
What SPL severity band is on file for Formoterol + Budesonide/Formoterol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Budesonide/Formoterol has 5 labeled pairs on file vs Formoterol's 3. In the moderate band specifically: Formoterol has 3 (also Aclidinium, Glycopyrrolate/Formoterol); Budesonide/Formoterol has 4 (also Ketoconazole, Clarithromycin, Itraconazole).
What mechanism field is on file for Formoterol and Budesonide/Formoterol?
These medicines can work together to increase the effects of formoterol on your heart and blood vessels. This can lead to changes in your heart rate or blood pressure.
Budesonide/Formoterol's labeled portfolio outnumbers Formoterol
SPL source-record counts only. This page's band is moderate · classes on file: Formoterol (Long-Acting Beta-2 Agonist (LABA)); Budesonide/Formoterol (Corticosteroid / Long-Acting Beta-2 Agonist Combination).
0 major · 3 moderate · 0 minor · 3 total
- Other moderate peers for Formoterol
- Aclidinium
- Glycopyrrolate/Formoterol
0 major · 4 moderate · 1 minor · 5 total
- Other moderate peers for Budesonide/Formoterol
- Ketoconazole
- Clarithromycin
- Itraconazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.