Formoterol and Glycopyrrolate/Formoterol Interaction

Drug interaction information between Formoterol and Glycopyrrolate/Formoterol.

Formoterol and Glycopyrrolate/Formoterol have a documented moderate interaction in FDA labeling.

FDA drug labeling documents a moderate-severity interaction between Formoterol and Glycopyrrolate/Formoterol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.

Drug A

Formoterol

Long-Acting Beta-2 Agonist (LABA)

Drug B

Glycopyrrolate/Formoterol

LAMA / LABA Combination

How They Interact

Taking two drugs that work the same way can cause a stronger effect on your heart and nervous system. This happens because both drugs stimulate the same receptors in your body.

FDA Label Information

May potentiate effect of formoterol fumarate on cardiovascular system. ( 7.6 ) 7.1 Adrenergic Drugs If additional adrenergic drugs are to be administered by any route, they should be used with caution because the sympathetic effects of formoterol, a component of BEVESPI AEROSPHERE, may be potentiated [see Warnings and Precautions (5.3) ] . 7.2 Xanthine Derivatives, Steroids, or Diuretics Concomitant treatment with xanthine derivatives, steroids, or diuretics may potentiate any hypokalemic effect of beta 2 adrenergic agonists such as formoterol, a component of BEVESPI AEROSPHERE.

Frequently Asked Questions

What SPL severity band is on file for Formoterol + Glycopyrrolate/Formoterol?

Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.

Which drug in this pair has the larger labeled-interaction portfolio?

Formoterol has 3 labeled pairs on file vs Glycopyrrolate/Formoterol's 1. In the moderate band specifically: Formoterol has 3 (also Aclidinium, Budesonide/Formoterol); Glycopyrrolate/Formoterol has 1.

What mechanism field is on file for Formoterol and Glycopyrrolate/Formoterol?

Taking two drugs that work the same way can cause a stronger effect on your heart and nervous system. This happens because both drugs stimulate the same receptors in your body.

Formoterol's labeled portfolio outnumbers Glycopyrrolate/Formoterol

SPL source-record counts only. This page's band is moderate · classes on file: Formoterol (Long-Acting Beta-2 Agonist (LABA)); Glycopyrrolate/Formoterol (LAMA / LABA Combination).

Formoterol

0 major · 3 moderate · 0 minor · 3 total

Glycopyrrolate/Formoterol

0 major · 1 moderate · 0 minor · 1 total

Glycopyrrolate/Formoterol has no other moderate-band peer in this dataset besides Formoterol.

Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.