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fluvoxamine vs omeprazole

Side-by-side comparison of fluvoxamine and omeprazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

Based on a finding of substantial interactions of fluvoxamine with certain of these drugs (see later parts of this section and also WARNINGS AND PRECAUTIONS [ 5 ] for details) and limited in vitro data for CYP3A4, it appears that fluvoxamine inhibits several cytochrome P450 isoenzymes that are known to be involved in the metabolism of other drugs such as: CYP1A2 (e.g., warfarin, theophylline, propranolol, tizanidine), CYP2C9 (e.g., warfarin), CYP3A4 (e.g., alprazolam), and CYP2C19 (e.g., omeprazole). A clinically significant fluvoxamine interaction is possible with drugs having a narrow...

Recommendation: Your doctor may need to adjust your omeprazole dose or monitor you for side effects while you are taking both medications.

Drug Class
fluvoxamine Selective Serotonin Reuptake Inhibitor (SSRI)
omeprazole Proton Pump Inhibitor (PPI)
Type
fluvoxamine Prescription
omeprazole Over-the-Counter
Summary
fluvoxamine

Fluvoxamine is a medicine that can help treat obsessive compulsive disorder (OCD). It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).

omeprazole

Omeprazole (Prilosec) is a medicine that reduces the amount of acid in your stomach. It belongs to a class of drugs called proton pump inhibitors (PPIs).

What It Treats
fluvoxamine

Fluvoxamine is used to treat obsessive compulsive disorder (OCD). OCD involves having constant, unwanted thoughts or behaviors that you feel the need to repeat. These thoughts or actions can cause you distress and interfere with your daily life.

omeprazole

This medicine treats frequent heartburn, which is heartburn that occurs 2 or more days a week. It is not meant to give you immediate relief from heartburn. It may take 1 to 4 days for the medicine to fully work.

How It Works
fluvoxamine

Fluvoxamine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluvoxamine can help reduce the symptoms of OCD.

omeprazole

Omeprazole works by blocking the production of acid in your stomach. It does this by targeting the cells that make stomach acid. This helps to reduce heartburn symptoms.

Common Side Effects
fluvoxamine
  • Abnormal ejaculation
  • Loss of appetite
  • Problems having an orgasm
  • Weakness
  • Diarrhea
omeprazole
  • Headache
FAERS Reports
fluvoxamine
  • This medicine is interacting with another medicine 215
  • Feeling sick to your stomach 117
  • Sleepiness 114
  • Feeling worried or nervous 103
  • Thinking about suicide 96
omeprazole
  • Tiredness 19,903
  • Feeling sick to your stomach 19,841
  • Loose stools 19,625
  • Difficulty breathing 16,336
  • Headache 14,629
Serious Warnings
fluvoxamine

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. Tell your doctor right away if you have any sudden changes in mood, behavior, thoughts, or feelings, especially if they are new, get worse, or worry you. Watch for suicidal thoughts or actions. Families and caregivers should also be aware of these risks.

omeprazole

Children under 18 should ask a doctor before use. Heartburn in children may be a sign of a serious condition.

Pregnancy
fluvoxamine

Tell your doctor if you are pregnant or plan to become pregnant. Fluvoxamine may cause problems for the baby if taken during pregnancy. Fluvoxamine can pass into breast milk and may harm a nursing baby.

omeprazole

Talk to your doctor if you are pregnant or breastfeeding before taking this medicine. It is important to weigh the benefits and risks with your doctor.

Also Compare, Nearby Drugs

How to Read This fluvoxamine vs omeprazole Comparison

fluvoxamine is classified in the Selective Serotonin Reuptake Inhibitor (SSRI) drug class, while omeprazole sits within the Proton Pump Inhibitor (PPI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluvoxamine has 645 submissions while omeprazole has 90,334. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluvoxamine blocks the liver enzymes that are responsible for breaking down omeprazole. this can cause omeprazole levels to stay in your system longer than they should.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between fluvoxamine and omeprazole - always consult your physician or pharmacist first.

Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.