fluticasone vs fluticasone/umeclidinium/vilanterol
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Side-by-side comparison of fluticasone and fluticasone/umeclidinium/vilanterol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
( 7.5 ) 7.1 Inhibitors of Cytochrome P450 3A4 Fluticasone furoate and vilanterol are substrates of CYP3A4. Concomitant administration of the strong CYP3A4 inhibitor ketoconazole increases the systemic exposure to fluticasone furoate and vilanterol.
Flonase, Flovent
Trelegy Ellipta
Fluticasone is a steroid medicine that helps reduce inflammation in your nose. It can help relieve allergy symptoms.
Trelegy Ellipta is a medicine that contains three drugs in one inhaler. It helps people with COPD and asthma breathe easier.
Fluticasone temporarily relieves symptoms of hay fever or other upper respiratory allergies. These symptoms include a stuffy nose, itchy and watery eyes, itchy nose, runny nose, and sneezing. It can help you breathe easier and feel more comfortable when you have allergies.
Trelegy Ellipta is used to help people with chronic obstructive pulmonary disease (COPD) breathe better. It is also used to treat asthma in adults aged 18 and older. This medicine is not for sudden breathing problems.
Fluticasone is a corticosteroid. It works by reducing inflammation in the nasal passages. This helps to relieve allergy symptoms.
Trelegy Ellipta contains three medicines that work in different ways. Fluticasone reduces swelling in the lungs. Umeclidinium and vilanterol relax the muscles around your airways, making it easier to breathe.
- • Headache
- • Fatigue
- • Upper respiratory infection
- • Pneumonia
- • Bronchitis
- • Oral thrush (Candida)
- • Headache
- Headache 6,061
- Tiredness 5,935
- Difficulty breathing 5,830
- Feeling sick to your stomach 5,209
- Pain 4,528
No adverse event reports.
Children 4 to 11 years of age: The growth rate of some children may be slower while using this product. Children should use it for the shortest time needed to relieve symptoms. Talk to your child’s doctor if they need to use the spray for longer than two months a year.
LABA medicines like vilanterol can raise the risk of asthma-related problems. Do not use Trelegy Ellipta for sudden, severe COPD or asthma symptoms. Rinse your mouth after use to prevent thrush. Trelegy Ellipta may increase your risk of pneumonia. It can also weaken your immune system and raise your risk of infections. It may cause problems with your heart, blood pressure, blood sugar, or bones. Long-term use may lead to glaucoma or cataracts. Tell your doctor if your glaucoma or urinary retention gets worse.
It is not known if fluticasone will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if fluticasone passes into breast milk. Talk to your doctor if you are breastfeeding.
Not enough information exists to determine if Trelegy Ellipta is safe during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine passes into breast milk.
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How to Read This fluticasone vs fluticasone/umeclidinium/vilanterol Comparison
fluticasone is classified in the Corticosteroid drug class, while fluticasone/umeclidinium/vilanterol sits within the Triple Therapy (ICS/LAMA/LABA) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluticasone has 27,563 submissions while fluticasone/umeclidinium/vilanterol has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both of these medications contain the same steroid ingredient. taking them together increases the total amount of medicine in your body, which can lead to more side effects.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for fluticasone or fluticasone/umeclidinium/vilanterol.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.