felodipine vs ketoconazole
Side-by-side comparison of felodipine and ketoconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Co-administration of CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin, grapefruit juice, cimetidine) with felodipine may lead to several-fold increases in the plasma levels of felodipine, either due to an increase in bioavailability or due to a decrease in metabolism.
Recommendation: Your doctor may need to lower your dose of felodipine. Watch for signs of low blood pressure, such as dizziness or feeling faint.
Plendil
Nizoral
Felodipine is a drug that lowers your blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Felodipine treats high blood pressure (hypertension). Lowering your blood pressure helps prevent strokes and heart attacks. It's important to also manage other risk factors like cholesterol, diabetes, and smoking. You may need more than one medicine to control your blood pressure.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Felodipine is a calcium channel blocker. It works by relaxing and widening your blood vessels. This makes it easier for blood to flow, which lowers blood pressure.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
- • Swelling in your ankles or feet
- • Headache
- • Flushing (redness of face)
- • Feeling tired
No common side effects listed.
- Feeling tired 1,050
- Difficulty breathing 953
- Feeling lightheaded 946
- Loose stools 846
- Feeling sick to your stomach 846
- Feeling tired 929
- Itching 902
- Feeling sick to your stomach 834
- Skin breakout 802
- Loose stool 760
If you take certain medicines like ketoconazole, itraconazole, or erythromycin, talk to your doctor. These drugs can greatly increase the amount of felodipine in your blood, leading to unwanted effects. Also, if you take anticonvulsants like phenytoin, carbamazepine, or phenobarbital, felodipine may not work as well.
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if felodipine will harm your unborn baby. Talk to your doctor about breastfeeding while taking felodipine.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
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How to Read This felodipine vs ketoconazole Comparison
felodipine is classified in the Calcium Channel Blocker drug class, while ketoconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, felodipine has 4,641 submissions while ketoconazole has 4,227. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole blocks the enzyme that breaks down felodipine. this can cause felodipine levels to rise significantly in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between felodipine and ketoconazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.